Collecting E. Coli Samples from Patients with Recurrent Urinary Tract Infections
Systematic Analysis of Bacterial Multidrug Tolerance in Longitudinal Isolates of Patients That Are Prone to Developing Urinary Tract Infections
This study is collecting samples of E. coli from patients with recurring urinary tract infections to see how these bacteria behave and why they might keep coming back.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 45 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Université Catholique de Louvain Academic / other |
| Locations | 1 site (Brussels) |
| Trial ID | NCT05826067 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect clinical isolates of Escherichia coli from patients experiencing recurrent urinary tract infections. Samples will be gathered during routine medical procedures from patients with various conditions, including those with suprapubic or nephrostomy catheters. The study seeks to understand the persistence of E. coli strains in natural settings, which may contribute to chronic infections and antibiotic resistance. Detailed medical histories will be compiled to assess the impact of previous antibiotic treatments on infection recurrence.
Who should consider this trial
Good fit: Ideal candidates include hospitalized or ambulatory patients diagnosed with urinary tract infections caused by E. coli, particularly those with neurological disorders or requiring catheterization.
Not a fit: Patients who refuse treatment, are non-compliant with therapy, pregnant, or do not consent to participate may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for recurrent urinary tract infections caused by E. coli.
How similar studies have performed: While studies on E. coli and urinary tract infections exist, this specific approach focusing on natural strains and persistence is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients hospitalized for urinary tract infection, with or without neurological disorders (spina bifida, MS, paraplegic patients) or ambulatory patients diagnosed with a urinary tract infection when the identified causative agent is E. coli * patients who have or are planned to undergo the insertion of a suprapubic catheter * patients who have or are planned to undergo the insertion a nephrostomy catheter Exclusion Criteria: patients * refusing the planned treatment * with therapy compliance * pregnant women * who do not consent to participate
Where this trial is running
Brussels
- Cliniques universitaires Saint Luc — Brussels, Belgium (Recruiting)
Study contacts
- Study coordinator: Françoise Van Bambeke, PhD
- Email: francoise.vanbambeke@uclouvain.be
- Phone: +32-2-764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.