Collecting cancer samples to create living models for research
ORganoid GeneratioN Study for Cancer
This study is collecting cancer samples from patients to create lab-grown models that help researchers understand why some cancers respond to treatment better than others.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Royal Marsden NHS Foundation Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT05734963 on ClinicalTrials.gov |
What this trial studies
This observational study aims to collect cancer samples from patients undergoing surgery or biopsy to develop patient-derived organoid models. By growing these cancer cells in the laboratory, researchers hope to gain a better understanding of cancer biology and why some cancers respond to treatment while others do not. The study will utilize advanced techniques such as DNA sequencing and RNA gene expression analysis to analyze the samples. The ultimate goal is to improve treatment options and outcomes for cancer patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with histologically proven or suspected cancer who are undergoing an interventional procedure.
Not a fit: Patients who are unable to undergo sample collection or are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new treatments or improvements in existing therapies for cancer patients.
How similar studies have performed: Other studies have shown promise in developing organoid models for cancer research, indicating that this approach is both viable and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Patients with histologically proven or suspected cancer undergoing an interventional procedure, such as surgery or biopsy * Ability to give informed consent for biological sample collection Exclusion Criteria: * Unable to undergo sample collection * Pregnancy
Where this trial is running
London
- The Royal Marsden Hospital — London, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Ben O'Leary — Royal Marsden Hospital NHS Foundation Trust
- Study coordinator: Ben O'Leary
- Email: ben.oleary@icr.ac.uk
- Phone: 02071535337
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.