Collecting cancer samples to create living models for research

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect cancer samples from patients undergoing surgery or biopsy to develop patient-derived organoid models. By growing these cancer cells in the laboratory, researchers hope to gain a better understanding of cancer biology and why some cancers respond to treatment while others do not. The study will utilize advanced techniques such as DNA sequencing and RNA gene expression analysis to analyze the samples. The ultimate goal is to improve treatment options and outcomes for cancer patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Patients with histologically proven or suspected cancer undergoing an interventional procedure, such as surgery or biopsy
* Ability to give informed consent for biological sample collection

Exclusion Criteria:

* Unable to undergo sample collection
* Pregnancy

Where it's running

• The Royal Marsden Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Ben O'Leary — Royal Marsden Hospital NHS Foundation Trust
• Study coordinator: Ben O'Leary
• Email: ben.oleary@icr.ac.uk
• Phone: 02071535337

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Genetic Risk Profiling in Prostate Cancer: Patient and Provider Perspectives

  This study asks patients and their doctors how genetic risk profiling for prostate cancer might fit into routine care and decision-making.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07741929

• Short-course CT online-adaptive radiotherapy for post-operative endometrial cancer

  This trial tests whether delivering post-operative radiotherapy in 5 sessions using CT online-adaptive radiotherapy is safe and feasible for endometrial cancer patients.

  Recruiting Royal Marsden NHS Foundation Trust · Sutton · NCT07675733

• ctDNA-guided precision care for lung, GIST, colorectal, biliary, and ovarian cancers

  This trial tests a blood test that looks for tumor DNA in patients with several cancers to help guide personalized treatment decisions.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07673861

• Personalised neoadjuvant therapy planning for adults with high‑risk soft tissue sarcoma

  This project tests whether analyzing tumor tissue and clinical data can help guide neoadjuvant chemotherapy decisions for adults with high‑risk soft tissue sarcomas.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07432932

• Digital exercise program with live virtual group sessions for men on hormone therapy during radiotherapy

  This program will test whether a digital exercise program with live virtual group sessions helps men with prostate cancer who are starting or receiving hormone therapy with radiotherapy stick to exercise recommendations and improve health and fatigue.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07243834

• Immediate breast reconstruction using 3D imaging and simulation to measure effects of radiotherapy

  This project will test whether 3D surface photos and simulated images help women having a mastectomy with immediate reconstruction feel more confident about their likely appearance, help surgeons plan to reduce later correction surgery, and measure how radiotherapy changes breast shape.

  Recruiting Royal Marsden NHS Foundation Trust · London · NCT07136753

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.