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Cohort study on Crohn's Disease progression and treatment

The CROCO Study: CROhn's Disease COhort Study

Not applicable Interventional GLSMED Learning Health S.A. · NCT05420233

This study is trying to see how Crohn's Disease changes over time in newly diagnosed patients and how different treatments can help manage it better.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment600 (estimated)
Ages18 Years and up
SexAll
SponsorGLSMED Learning Health S.A. Academic / other
Locations20 sites (Liège, Liège and 19 other locations)
Trial IDNCT05420233 on ClinicalTrials.gov

What this trial studies

The CROCO Study aims to create a prospective cohort of patients diagnosed with Crohn's Disease (CD) within the last year, who will be closely monitored over a five-year period. This multicenter study will include 600 patients and utilize a treat-to-target strategy with the latest therapies, assessing disease progression through the Lémann Index and various imaging techniques. Patients will undergo regular evaluations, including clinical and laboratory assessments, to understand the long-term evolution of CD and the impact of different treatment strategies.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 years old who have been diagnosed with Crohn's Disease within the past 12 months.

Not a fit: Patients with severe underlying medical conditions, uncertain CD diagnosis, or those unable to undergo necessary imaging will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved management strategies and better outcomes for patients with Crohn's Disease.

How similar studies have performed: Other studies focusing on the long-term management and progression of Crohn's Disease have shown promising results, indicating that this approach is supported by previous research.

Eligibility criteria

Show full inclusion / exclusion criteria 
INCLUSION CRITERIA

To be eligible all of the following criteria must be met:

* Diagnosis of CD (according to ECCO guidelines) established within the past 12 months;
* Patients able to understand the information provided to them and to give written informed consent for the study;
* Male or female, age \> 18 years.

EXCLUSION CRITERIA:

* Patients unwilling or unable to provide informed, written consent;
* Severe underlying medical disorder with an anticipated life expectancy \< 2 years;
* Refusal or medical conditions (e.g. Glomerular filtration rate \< 30 mL/min) preventing cross-sectional imaging during follow-up;
* Uncertain CD diagnosis;
* Pregnancy (if it is impossible to implement the MRE at one year) or any other reason that makes resonance not feasible throughout the study (eg claustrophobia).

Where this trial is running

Liège, Liège and 19 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Crohn DiseaseCrohn DII
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.