Cohort for patients with psoriatic arthritis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The APACHE Cohort is a prospective national multicenter study that aims to follow patients with their first episode of peripheral arthritis attributed to psoriatic arthritis over a period of 10 years. The study will include 425 patients and will collect a variety of clinical data, patient-reported outcomes, and imaging results through standardized visits. The goal is to identify factors associated with aggressive disease patterns and to improve early treatment strategies. This observational study will not involve any therapeutic interventions but will provide valuable data for future research.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women or men aged from 18 to 65 inclusive
* First episode of peripheral arthritis in the last 12 months, authenticated by a rheumatologist
* Psoriasis diagnosed by a practitioner or family history of psoriatic arthritis (first-degree relative \[parent or sibling\] or second degree relative)
* Arthritis most likely recognized as a psoriatic arthritis by a rheumatologist (diagnostic confidence score : ≥ 7 out of 10)
* Signed informed consent form
* Affiliation to a social security system

Exclusion Criteria:

* Formal diagnostic of inflammatory rheumatism other than psoriatic arthritis
* Treatment or history of treatment with a biomedicine
* Patient receiving csDMARDS (methotrexate, sulfasalazine, or leflunomide) or apremilast treatment over the past year for rheumatological symptoms
* Oral steroids in the last 4 weeks, above 10 mg/d of prednisone or with modified dosage
* intravenous or intra articular steroids in the last 4 weeks
* IRM contraindication
* Cognitive, mental or psychic disorders impeding protocol accomplishment
* Difficulties with French language understanding
* Patient under tutorship or curatorship
* Pregnancy

Where it's running

• Henri-Mondor Hospital
  Créteil, France Recruiting
• Lapeyronie Hospital
  Montpellier, France Recruiting
• Saint Joseph Hospital
  Paris, France Recruiting

Study contacts

• Study coordinator: Pascal CLAUDEPIERRE, PHD
• Email: pascal.claudepierre@aphp.fr
• Phone: 01 49 81 47 04

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.