Cognitive training using virtual reality to improve long-term memory
Virtual Reality Interventions to Stimulate Capabilities for Learning and Retrieval of High-Fidelity Memory
This study tests whether playing a virtual reality game can help older adults and people with mild cognitive impairment improve their long-term memory.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT05625425 on ClinicalTrials.gov |
What this trial studies
This intervention focuses on enhancing long-term memory capabilities in older adults and patients with mild cognitive impairment through an immersive video game experience. The study utilizes virtual reality technology to create a wayfinding game that encourages participants to navigate complex environments, promoting cognitive engagement and neuroplasticity. By targeting the hippocampus, the intervention aims to improve memory retention and cognitive control, potentially reversing or mitigating memory decline. Participants will engage in semi-weekly sessions to assess the effectiveness of this innovative approach.
Who should consider this trial
Good fit: Ideal candidates include fluent English speakers with mild cognitive impairment who have completed at least 12 years of education and can comfortably engage in virtual reality experiences.
Not a fit: Patients with a history of concussions, balance issues, or those taking psychotropic medications may not benefit from this intervention.
Why it matters
Potential benefit: If successful, this intervention could significantly improve memory function and quality of life for individuals experiencing cognitive decline.
How similar studies have performed: Preliminary results from similar cognitive training interventions have shown promise, suggesting that this approach may yield beneficial outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * fluent speakers of English * completed 12 or more years of education * normal or corrected-to-normal vision * dexterity to comfortably operate the scanner-compatible response box * freedom from physical and neurological conditions contra-indicated for fMRI * must confirm physical stamina and comfort for semi-weekly brisk 30-minute walks on level ground Exclusion Criteria: * use of psychotropic medications * history of concussions or dizziness, vestibular or balance problems * significant discomfort with virtual reality experiences
Where this trial is running
San Francisco, California
- UCSF Mission Bay — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Peter E Wais, PhD — Neuroscape, Department of Neurology
- Study coordinator: Melissa Arioli
- Email: twist.study@ucsf.edu
- Phone: 415-502-7321
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.