Cognitive testing for stress-induced exhaustion and depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The PrimeCog project aims to differentiate between stress-induced exhaustion disorder (SED) and major depressive disorder (MDD) by analyzing symptomatology and pathophysiology in comparison to healthy controls. Participants, aged 18 to 65, will be recruited from primary care centers and will undergo a series of assessments including digital cognitive tests, blood, saliva, and hair sample collection, as well as MRI scans of the brain. This multicenter longitudinal study will track changes over 12 and 24 months to identify biomarkers and cognitive differences among the groups. The goal is to develop new diagnostic tools that can guide individualized treatment strategies based on cognitive function and underlying biological mechanisms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. adults 18 to 65 years old;
2. fluent in Swedish;
3. corrected to normal vision and hearing;
4. (for cases), newly diagnosed with MDD or SED (i.e., received as new diagnosis at the visit to the physician) according to the diagnostic criteria from DSM-V (MDD) and the Swedish Board of Health and Welfare (SED)

Exclusion Criteria:

1. already ongoing treatment for MDD/SED or previous diagnosis of MDD/SED within the last year;
2. history of serious mental illness (defined as mental illness that has required psychiatric in-patient care);
3. acute cerebrovascular event or severe head trauma in the last 6 months;
4. known cognitive impairment;
5. substance dependence, ongoing or past;
6. motor disability or impairment affecting interaction with the digital tests;
7. photosensitive epilepsy or -migraines.

For the MRI subgroup, any contraindication to MRI is an exclusion criterion.

Where it's running

• Region Ostergotland, primary care centrum
  Linköping, Östergötland County, Sweden Recruiting

Study contacts

• Principal investigator: Hanna Israelsson Larsen, PhD — Region Ostergotland/Linkoping University
• Study coordinator: Hanna Israelssion Larsen, PhD
• Email: hanna.israelsson.larsen@regionostergotland.se
• Phone: +46738317008

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.