Cognitive Behavioral Therapy via Mobile App for Functional Dyspepsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of an 8-week smartphone-based cognitive behavioral therapy (CBT) program for patients suffering from refractory functional dyspepsia. The approach aims to determine if mobile CBT can reduce symptoms as effectively as conventional pharmacotherapy, specifically antipsychotic medications, which are associated with adverse effects. Participants will be monitored for symptom improvement and overall quality of life. The study includes patients aged 18-80 who have not responded to standard treatments for functional dyspepsia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 18-80
2. Refractory functional dyspepsia (patients with Rome IV functional dyspepsia remained symptomatic after treatment of 8 weeks of proton pump inhibitor and 4 weeks of prokinetics)
3. Negative or unrelated-to-FD symptom findings of gastroscopy, upper abdominal ultrasound, Hp test and routine blood tests within the past 1 year.

Exclusion Criteria:

1. Severe mental illness (PHQ-9 ≥20 or GAD-7 ≥15) or suicidal ideation;
2. Known hp infection, active gastrointestinal peptic ulcer, cholecystitis, gallstones, suspected or known bowel obstruction, gastroparesis, major gastrointestinal surgery etc.;
3. Known or suspected malignant tumor, significant heart/brain/liver/kidney diseases, obvious hematologic abnormalities or endocrine diseases etc., which may be -related to FD symptoms;
4. Known or suspected drug-related FD (e.g.NSAIDs-related FD);
5. Unable to access to mobile networks or unable to manage mobile APP properly.
6. Allergy or other contradictions to flupenthixol or melitracen
7. Taking any antipsychotics drugs or CBT interference within 12 weeks
8. Pregnant or lactating women;
9. Unable to provide informed consent.

Where it's running

• Hainan General Hospital (Hainan Affifiliated Hospital ofHainan Medical University)
  Haikou, Hainan, China Recruiting
• Air Force Military Medical University, China
  Xi'an, Shaanxi, China Recruiting
• Shaanxi Second People's Hospital
  Xi'an, Shaanxi, China Recruiting
• Xi'an 986 Hospital
  Xi'an, Shaanxi, China Recruiting
• Mianyang Third Hospital
  Mianyang, Sichuan, China Recruiting
• Tangdu Hospital
  Xi'an, Shaanxi, China Not yet recruiting

Study contacts

• Study coordinator: Yanglin Pan, Professor
• Email: yanglinpan@hotmail.com
• Phone: 13991811225

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Low-FODMAP Diet vs Standard Dietary Advice for Functional Dyspepsia

  This study tests whether a low-FODMAP diet helps adults with functional dyspepsia compared with standard dietary advice.

  Recruiting King Chulalongkorn Memorial Hospital · Bangkok, Pathumwan · NCT07925073

• Pain Reprocessing Therapy for Functional Dyspepsia

  A small pilot test to see if a psychological therapy that uses exposure techniques can lessen digestive symptoms and help daily functioning in people with functional dyspepsia.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07838324

• Identifying Signatures of Gut Interoception in Functional Dyspepsia and Anorexia Nervosa

  This study tests how the gut-brain connection works in people with functional dyspepsia or anorexia nervosa using brain imaging.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07772167

• Prevalence and possible role of non-H. pylori Helicobacter species in gastric conditions and cancers

  Researchers will test stomach tissue from people with functional dyspeasia, various gastritis conditions, gastric cancer, and bariatric patients to see if non-H. pylori Helicobacter species are present.

  Recruiting at 3 sites Universiteit Antwerpen · Edegem and 2 other locations · NCT07770126

• Liver Fat and Scarring in People Suspected of Non-Celiac Wheat Sensitivity

  This study looks to see if people with non-celiac wheat sensitivity have liver fat or fibrosis and how this relates to IBS/FD and celiac disease.

  Recruiting at 2 sites University of Palermo · Palermo, Palermo and 1 other locations · NCT07750535

• Prevalence of Functional Dyspepsia in a Rural Community in Bangladesh

  This study tests how common functional dyspepsia is in a rural Bangladeshi community among adults who live there.

  Recruiting Bangladesh Medical University · Dhaka · NCT07694778

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.