Clinical trial Recruiting at 1 site Interventional

Closing the appendix stump with clips versus ties during laparoscopic appendectomy

Official title: Results of Laparoscopic Appendectomy With Application of Clips Versus Ligature for Stump Closure: A Comparative Study

Run by Sohag University · NCT07115303 · Data updated 2026-11-12

This study tests whether using metal clips or tying sutures to close the appendix stump during laparoscopic appendectomy leads to fewer complications and lower costs for people with acute appendicitis.

Quick facts

Study typeInterventional
SexAll
Enrollment80 (estimated)
SponsorSohag University
Academic / other
Locations1 site (Sohag)
StatusRecruiting
StartedJuly 14, 2025
Main results expectedFebruary 28, 2026
Study endsFebruary 28, 2026
Registry record updatedAugust 11, 2025
Trial IDNCT07115303 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are patients of any age or sex presenting to the emergency department with uncomplicated acute appendicitis who are treated at Sohag University Hospital.

Probably not a fit

Patients with complicated appendicitis, unstable cardiac or pulmonary problems, or those found to have suspected Crohn's disease or an intraoperative mass are excluded and may not benefit from the findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective comparison of two techniques for closing the appendiceal stump during laparoscopic appendectomy: application of clips versus ligature (tying sutures). Patients of any age or sex who present with uncomplicated acute appendicitis at Sohag University Hospital are enrolled, while those with complicated appendicitis, unstable cardiac or pulmonary conditions, or intraoperative suspicion of Crohn's disease or a mass are excluded. Outcomes include technical feasibility, postoperative complications such as fecal fistula, and economic considerations. Procedures are performed at a single center and data are collected during the perioperative and early postoperative period.

Why it matters

Potential benefit: If successful, the trial could identify a safer and more cost-effective method to close the appendix stump in uncomplicated laparoscopic appendectomy.

How similar studies have gone: Previous surgical series comparing clips, ligatures (endoloops), and staplers for stump closure in uncomplicated appendicitis have shown mixed but generally comparable safety and cost profiles for clips versus ties.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Any patient diagnosed with acute appendicitis of any age and of any sex presented to ER of the Department of General, Laparoscopic and Oncologic Surgery Department, Sohag University Hospital will be enrolled in this study.

Exclusion Criteria:

* Patients with complicated appendicitis.
* Patients with unstable cardiac or pulmonary condition.
* Patients with suspicious crhon's disease or mass intraoperative.

Where it's running

  • Sohag university hospital
    Sohag, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.