Chronic Stress and Pancreatic Cancer Outcomes in People with Pancreatic Cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, prospective observational study that follows adults with pancreatic cancer to see if chronic stress—measured by mood, anxiety, sleep quality, and related biomarkers—is linked to disease progression, treatment outcomes, and survival. Participants complete standardized questionnaires at baseline and during follow-ups, while clinical data are extracted from medical records and a small blood sample is stored for later analysis. Follow-ups occur at key points during therapy and every 3 months thereafter, with psychological measures and clinical outcomes tracked continuously. The study does not assign any treatments but observes real-world care to identify possible associations between stress and prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years.
* Histologically or cytologically confirmed diagnosis of pancreatic cancer, or other pancreatic diseases.
* Conscious, with basic reading/writing or communication skills, able to understand and complete the questionnaire assessments (either independently, with assistance from research staff, or with help from a family member).
* Voluntarily agree to participate in this study and sign a written informed consent form.

Exclusion Criteria:

* Presence of severe cognitive impairment (e.g., dementia, disturbance of consciousness) or a definite history of psychiatric disorders, judged by the investigator as unable to comply with the study assessments, and without a family member who can help complete the questionnaire assessments.
* Presence of other severe, uncontrolled systemic diseases (e.g., severe heart, lung, or kidney failure), with an estimated life expectancy \< 3 months as judged by the investigator.
* Inability to understand Chinese or presence of severe visual/hearing impairment that affects completion of the questionnaire assessments, and without a family member who can help complete the questionnaire assessments.

Where it's running

• Zhongshan Hospital Affiliated to Fudan University
  Shanghai, Shanghai Municipality, China Recruiting
• the Third Xiangya Hospital of Central South University
  Changsha, Hunan, China Not yet recruiting
• The First Affiliated Hospital of Xi'an Jiao Tong University
  Xi’an, Shanxi, China Not yet recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.