Chronic remote ischaemic preconditioning for lowering blood pressure in older adults
The Effect of Chronic Remote Ischaemic Preconditioning on Blood Pressure in Older Adults
This study is testing if a new method called remote ischaemic preconditioning can help lower blood pressure and improve blood vessel health in older adults aged 65 to 85.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 65 Years to 85 Years |
| Sex | All |
| Sponsor | University of Nottingham Academic / other |
| Locations | 1 site (Derby, Derbyshire) |
| Trial ID | NCT05971407 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of chronic remote ischaemic preconditioning (RIPC) on improving vascular health and lowering blood pressure in older adults aged 65 to 85. RIPC involves inducing temporary, non-lethal ischaemia in one area of the body to protect other tissues from ischaemic events. The study aims to provide a non-pharmacological alternative to traditional hypertension treatments, which often lead to polypharmacy and associated risks in the elderly population. Participants will be randomly assigned to receive either RIPC or a sham treatment to assess the efficacy of this intervention.
Who should consider this trial
Good fit: Ideal candidates for this study are older adults aged between 65 and 85 who are physically able to perform the RIPC procedure.
Not a fit: Patients with active cardiovascular, cerebrovascular, or respiratory diseases, or those with significant comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could offer a safer, non-drug method to manage hypertension and improve vascular health in older adults.
How similar studies have performed: While the concept of remote ischaemic conditioning is gaining interest, this specific approach in older adults for hypertension is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant is aged \>65y and \<85y. * Participant is willing and able to give informed consent for participation in the study. * Participant is physically able to perform RIPC. Exclusion Criteria: * A BMI \<18 or \>35 kg/m2 * Active cardiovascular, cerebrovascular or respiratory disease: e.g. uncontrolled hypertension (BP \> 160/100), active angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt, recent cardiac event, COPD, pulmonary hypertension or recent (6 mo) stroke. * If history of hypertension, no recent alteration to antihypertensive medication (3 months). * A history of, or current neurological or musculoskeletal conditions (e.g. epilepsy) * Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance
Where this trial is running
Derby, Derbyshire
- School of Medicine, Royal Derby Hospital Site, University of Nottingham — Derby, Derbyshire, United Kingdom (Recruiting)
Study contacts
- Principal investigator: Timothy England, MB ChB PhD — University of Nottingham
- Study coordinator: Harry G Keevil, MB BChir
- Email: harry.keevil@nottingham.ac.uk
- Phone: 01332 724687
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.