Chlordecone exposure and women's fertility
Official title: KARU-FERTIL: Chlordecone Exposure and Female Fertility
Run by Centre Hospitalier Universitaire de la Guadeloupe · NCT07231510 · Data updated 2026-11-12
This project will test whether past exposure to the pesticide chlordecone is linked to lower anti-Mullerian hormone (AMH) levels in women aged 18–39 who seek infertility care in Guadeloupe.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 39 Years |
| Sex | Women only |
| Enrollment | 634 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de la Guadeloupe Academic / other |
| Locations | 1 site (Pointe-à-Pitre) |
| Status | Recruiting |
| Started | January 26, 2024 |
| Main results expected | January 26, 2026 |
| Study ends | January 26, 2028 |
| Registry record updated | November 17, 2025 |
| Trial ID | NCT07231510 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–39 who are consulting for couple infertility at the CCMR (University Hospital of Guadeloupe) and who provide free, informed, written consent.
✕Probably not a fit
Women outside the 18–39 age range, those not seeking infertility care at CCMR, or those whose infertility is clearly due to non-environmental causes may not gain direct benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study will enroll women aged 18–39 who attend the Centre Caribéen de Médecine de la Reproduction (CCMR) at the University Hospital of Guadeloupe and obtain informed consent. Researchers will measure blood chlordecone concentrations and anti-Mullerian hormone (AMH) as a marker of ovarian reserve, and may collect samples for non-targeted environmental exposure testing and vaginal/endometrial microbiome analysis. This is an observational analysis that will look for statistical associations between chlordecone exposure and AMH while accounting for clinical and other exposure factors. Results will help clarify whether persistent environmental contamination in the French West Indies is associated with reduced ovarian reserve.
Why it matters
Potential benefit: If a link is confirmed, the results could help identify environmental causes of reduced ovarian reserve and guide public-health actions and fertility counseling for affected women.
How similar studies have gone: Animal studies have consistently reported that chlordecone impairs ovulation and reduces ovarian reserve, but no human studies have yet directly linked chlordecone exposure to female fertility.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged from 18 to 39 years * Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe * Free, informed and written consent Exclusion Criteria: * Women aged from 18 to 39 years * Consulting for couple infertility at the Centre Caribéen de Médecine de la Reproduction (CCMR, Caribbean Center for Reproductive Medicine) of the University Hospital of Guadeloupe * Free, informed and written consent
Where it's running
-
Chu de La Guadeloupe
Pointe-à-Pitre, Guadeloupe Recruiting
Study contacts
- Study coordinator: Mélanie petapermal
- Email: melanie.petapermal@chu-guadeloupe.fr
- Phone: +590590934667
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AI into Ultrasound Diagnostics in Reproductive Medicine
Researchers are testing AI tools that analyze transvaginal ultrasound images to help detect endometriosis, adenomyosis, uterine masses, and pregnancy-related receptivity in women aged 18-45.
-
Tadalafil to increase uterine lining and improve frozen embryo transfer success
This test sees if adding daily tadalafil to standard estrogen helps women with unexplained infertility using good-quality day‑5 frozen embryos get a thicker uterine lining and better transfer outcomes.
-
FET-LET-2x2: Testing natural vs medicated natural cycles for frozen embryo transfer
This study tests four approaches to preparing the uterus for frozen embryo transfer to see which yields the best pregnancy rate in women undergoing IVF.
-
Integrative care guided by biological aging markers for unexplained female infertility
This trial tests whether measuring telomeres and other biological aging markers can guide a personalized integrative treatment to help women aged 25–42 with persistent unexplained infertility improve their chances of pregnancy.
-
How fitness, heart health, and mental well-being relate to assisted fertility treatments
This study tries to see if physical activity, cardiorespiratory fitness, cardiovascular health, sleep, and stress affect pregnancy chances for women undergoing assisted fertility treatments.
-
How attitudes toward artificial intelligence relate to anxiety and quality of life in women receiving infertility treatment
This study will test whether women's attitudes toward artificial intelligence are linked to their anxiety and quality of life while undergoing infertility treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.