Chios mastic water for dyspepsia
Official title: The Effectiveness of a Natural Aqueous Extract of Chios Mastic in the Management of Dyspepsia: the MASTIQUA-D Randomized Controlled Clinical Trial
Run by Harokopio University · NCT06909890 · Data updated 2026-11-12
This 3-month randomized, double-blind test will see if adults aged 30–60 with dyspepsia feel better when they drink 600 mL per day of a carbonated beverage containing Chios mastic water versus a placebo beverage.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 30 Years to 60 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Harokopio University Academic / other |
| Locations | 1 site (Kallithea, Attica) |
| Status | Recruiting |
| Started | July 10, 2025 |
| Main results expected | April 2026 |
| Study ends | December 2026 |
| Registry record updated | September 15, 2025 |
| Trial ID | NCT06909890 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 30–60 with dyspepsia, BMI 20–35 kg/m2, without major chronic or chronic gastrointestinal diseases, not taking excluded medications or supplements, and not pregnant or breastfeeding.
✕Probably not a fit
Patients with other chronic gastrointestinal disorders, major chronic diseases, those taking immunosuppressants/antibiotics/anti-inflammatories or Chios mastic products, pregnant or breastfeeding women, or those unable to follow the protocol may not benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a 3-month randomized, double-blind, controlled intervention comparing a carbonated beverage enriched with 0.2% Chios mastic water (600 mL/day) to an identical placebo beverage in adults with dyspepsia. Participants are enrolled at Harokopio University and undergo baseline and post-intervention assessments. Outcomes include dyspepsia symptom severity, quality of life, anthropometric measures, lifestyle habits, and biochemical markers. The trial tests a liquid by-product formulation of Chios mastic that builds on prior work with the resin.
Why it matters
Potential benefit: If successful, it could offer an easy, natural beverage option to reduce dyspepsia symptoms and improve quality of life.
How similar studies have gone: Chios mastic resin has prior clinical evidence and EMA recognition for mild dyspeptic disorders, so this trial builds on existing positive findings though the aqueous 'mastic water' beverage is a novel formulation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 30-60 years old. * Body mass index of 20-35 kg/m2. * Presence of dyspepsia. Exclusion Criteria: * Presence of chronic diseases (e.g. diabetes mellitus, cancer, cardiovascular, hepatic, renal, respiratory, chronic inflammatory and psychiatric diseases). * Presence of other chronic gastrointestinal diseases (e.g. gastroesophageal reflux, inflammatory bowel disease and celiac disease). * Use of immunosuppressants, anti-inflammatories, antibiotics and corticosteroids. * Use of dietary supplements or other products with Chios mastic. * Excessive alcohol consumption (\>210 g and \>140 g of ethanol per week for men and women, respectively). * Currently on a weight-loss diet or recent (within 6 months) significant change in lifestyle habits. * Pregnancy or breast feeding (for women)
Where it's running
-
Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens
Kallithea, Attica, Greece Recruiting
Study contacts
- Principal investigator: Giannis Arnaoutis, PhD — Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University of Athens
- Study coordinator: Giannis Arnaoutis, PhD
- Email: garn@hua.gr
- Phone: +302109549100
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.