Chest CT patterns in rheumatoid arthritis–related interstitial lung disease
Official title: Radiologic Features of Patients With Rheumatoid Arthritis Related Interstitial Lung Disease at Chest High Resolution Computed Tomography
Run by Azienda Unita Sanitaria Locale di Piacenza · NCT07174102 · Data updated 2026-11-12
This project will use high-resolution chest CT scans to see if certain lung imaging patterns are linked with rheumatoid arthritis by comparing people with RA, idiopathic pulmonary fibrosis, and other connective tissue diseases.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Azienda Unita Sanitaria Locale di Piacenza Academic / other |
| Locations | 5 sites (Prague and 4 other locations) |
| Status | Recruiting |
| Started | January 8, 2025 |
| Main results expected | January 2035 |
| Study ends | January 2035 |
| Registry record updated | September 15, 2025 |
| Trial ID | NCT07174102 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis, or another connective tissue disease who have undergone or will undergo clinically indicated chest HRCT and can give informed consent.
✕Probably not a fit
People without RA, IPF, or other connective tissue diseases, those who have not had an HRCT as part of care, children, or those unable to give consent are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicenter observational longitudinal study that reviews high-resolution computed tomography (HRCT) scans from adults with rheumatoid arthritis, idiopathic pulmonary fibrosis, or other connective tissue diseases. Investigators will record the frequency of HRCT patterns such as fibrosis, nodules, and bronchiectasis and search for features that may be specific to RA. The study will also analyze relationships between imaging features and patients' demographic, clinical, and serologic characteristics. Where available, RA-ILD imaging will be directly compared with IPF and other CTD-ILD cohorts to identify distinguishing signs.
Why it matters
Potential benefit: If successful, the findings could help doctors recognize RA-specific lung imaging features earlier, improving diagnosis, prognosis, and treatment planning.
How similar studies have gone: Previous smaller studies have described HRCT patterns in mixed connective tissue disease populations, but RA-specific imaging signatures remain poorly defined and not yet validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients able to give their informed consent * at least aged 18 years * patients undergoing High-Resolution Computed Tomography (HRCT) for clinical needs at any point in their medical history * patients with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis or connective tissue disease Exclusion criteria: Patients younger than 18 and unable to give their informed consent.
Where it's running
-
UOC Reumatologia, Arcipedale Sant'Anna
Ferrara, Italy Recruiting -
SC Malattie Apparato Respiratorio, Azienda Policlinico di Modena
Modena, Italy Recruiting -
Local Health Unit ("Azienda Unità Sanitaria Locale", AUSL) of Piacenza
Piacenza, Italy Recruiting -
AUSL-IRCCS di Reggio Emilia
Reggio Emilia, Italy Recruiting -
Institute of Rheumatology, Na Slupi 4
Prague, Czechia Not yet recruiting
Study contacts
- Study coordinator: Marco Sebastiani, MD
- Email: m.sebastiani@ausl.pc.it
- Phone: +39 0523302645
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.