Chest CT patterns in rheumatoid arthritis–related interstitial lung disease
Radiologic Features of Patients With Rheumatoid Arthritis Related Interstitial Lung Disease at Chest High Resolution Computed Tomography
This project will use high-resolution chest CT scans to see if certain lung imaging patterns are linked with rheumatoid arthritis by comparing people with RA, idiopathic pulmonary fibrosis, and other connective tissue diseases.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Azienda Unita Sanitaria Locale di Piacenza Academic / other |
| Locations | 5 sites (Prague and 4 other locations) |
| Trial ID | NCT07174102 on ClinicalTrials.gov |
What this trial studies
This is a multicenter observational longitudinal study that reviews high-resolution computed tomography (HRCT) scans from adults with rheumatoid arthritis, idiopathic pulmonary fibrosis, or other connective tissue diseases. Investigators will record the frequency of HRCT patterns such as fibrosis, nodules, and bronchiectasis and search for features that may be specific to RA. The study will also analyze relationships between imaging features and patients' demographic, clinical, and serologic characteristics. Where available, RA-ILD imaging will be directly compared with IPF and other CTD-ILD cohorts to identify distinguishing signs.
Who should consider this trial
Good fit: Adults (18+) with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis, or another connective tissue disease who have undergone or will undergo clinically indicated chest HRCT and can give informed consent.
Not a fit: People without RA, IPF, or other connective tissue diseases, those who have not had an HRCT as part of care, children, or those unable to give consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could help doctors recognize RA-specific lung imaging features earlier, improving diagnosis, prognosis, and treatment planning.
How similar studies have performed: Previous smaller studies have described HRCT patterns in mixed connective tissue disease populations, but RA-specific imaging signatures remain poorly defined and not yet validated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients able to give their informed consent * at least aged 18 years * patients undergoing High-Resolution Computed Tomography (HRCT) for clinical needs at any point in their medical history * patients with a diagnosis of rheumatoid arthritis, idiopathic pulmonary fibrosis or connective tissue disease Exclusion criteria: Patients younger than 18 and unable to give their informed consent.
Where this trial is running
Prague and 4 other locations
- Institute of Rheumatology, Na Slupi 4 — Prague, Czechia (Not_yet_recruiting)
- UOC Reumatologia, Arcipedale Sant'Anna — Ferrara, Italy (Recruiting)
- SC Malattie Apparato Respiratorio, Azienda Policlinico di Modena — Modena, Italy (Recruiting)
- Local Health Unit ("Azienda Unità Sanitaria Locale", AUSL) of Piacenza — Piacenza, Italy (Recruiting)
- AUSL-IRCCS di Reggio Emilia — Reggio Emilia, Italy (Recruiting)
Study contacts
- Study coordinator: Marco Sebastiani, MD
- Email: m.sebastiani@ausl.pc.it
- Phone: +39 0523302645
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.