Chemotherapy effects on reflexes that control muscle responses and blood pressure during exercise
Official title: Effects of Chemotherapy Treatment on Metaboreflex, Mechanoreflex, and Baroreflex Function: PROTECT-08B Study
Run by Centre Paul Strauss · NCT07069790 · Data updated 2026-11-12
This test will see if women finishing chemotherapy for breast cancer have overactive muscle reflexes and altered blood-pressure control that reduce exercise ability compared with similar healthy women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 24 (estimated) |
| Sponsor | Centre Paul Strauss Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | October 2, 2025 |
| Main results expected | October 2, 2026 |
| Study ends | October 2, 2026 |
| Registry record updated | December 31, 2025 |
| Trial ID | NCT07069790 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women with stage I–III breast cancer who completed (neo)adjuvant chemotherapy less than three weeks ago, with no major chronic, psychiatric, musculoskeletal, or neurological conditions, are the intended participants.
✕Probably not a fit
Women with a history of other cancers, chronic medical conditions, implanted pacemakers, pregnancy, or contraindications to transient blood-flow occlusion are not eligible and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, cross-sectional study compares women with stage I–III breast cancer who have completed (neo)adjuvant chemotherapy within the past three weeks to age-, weight-, and activity-matched healthy women. Each participant completes a single 2 hour 25 minute session during which neuromuscular fatigue tests and cardiovascular measurements are performed. Non-invasive probes—post-exercise circulatory occlusion (PECO) and passive leg movement (PLM)—are used to probe metaboreflex and mechanoreflex activity, and a direct method is used to measure baroreflex sensitivity. The study compares reflex-driven cardiovascular responses and fatigue profiles between patients and controls to clarify chemotherapy-related changes.
Why it matters
Potential benefit: If successful, the results could help design targeted rehabilitation or protective strategies to reduce fatigue and improve exercise capacity after chemotherapy.
How similar studies have gone: Previous research has linked chemotherapy to increased central fatigue and altered cardiovascular reflexes, but combining PECO, PLM, and direct baroreflex measures in this patient group is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patient group : * Stage I to III breast cancer * Having completed (neo)adjuvant chemotherapy treatment less than three weeks ago Control group : \- healthy women (no history of cancer) of similar age, weight, and physical activity level Exclusion Criteria: * History of cancer * Any known chronic pathology * Protected minor or adult * Psychiatric, musculoskeletal or neurological problems * Implantation of a pacemaker * Pregnant woman * Presenting at least one contraindication to the use of transient blood flow occlusion
Where it's running
-
Institut de cancérologie Strasbourg Europe
Strasbourg, France Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Treatment choices and outcomes for early luminal breast cancer patients eligible for EndoPredict testing
This project will see how EndoPredict testing relates to treatment choices and long-term outcomes for adults with early ER-positive/HER2-negative breast cancer.
-
Radiation therapy for inoperable breast cancer
This trial will try adding a short, high-dose whole-breast radiation course with a focused boost to usual breast cancer medicines for people with locally advanced breast cancer who cannot or do not want surgery.
-
Personalized external beam radiation for localised breast and prostate tumours
This project will test whether using optimized MRI scans plus lab-grown tumor samples can help personalize external beam radiation for adults with localized breast or prostate cancer.
-
Predicting outcomes for advanced breast cancer patients treated with CDK4/6 inhibitors and endocrine therapy
This study is trying to see how well different CDK4/6 inhibitors combined with hormone therapy work for people with advanced breast cancer and how safe they are.
-
Radiation before mastectomy with immediate breast reconstruction
This trial tests whether giving radiation before mastectomy combined with immediate breast reconstruction improves cosmetic results and quality of life for women who need mastectomy and post‑mastectomy radiation.
-
Neoadjuvant treatment for lymph node-positive HR+ breast cancer
This study is testing if combining a new immunotherapy drug with different types of radiation and chemotherapy can help people with lymph node-positive HR+ breast cancer respond better to treatment before surgery.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.