Characterizing Repetitive Behaviors in OCD and Tic Disorders
Actimetric and Electrophysiological Analyses of Repetitive Behaviors (Tics and Compulsions)
NA · Institut National de la Santé Et de la Recherche Médicale, France · NCT06050369
This study is testing if special brain activity measurements can help tell the difference between compulsions in OCD and tics in Tourette syndrome to improve treatment options for people aged 15 to 65.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 15 Years to 65 Years |
| Sex | All |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France (other gov) |
| Locations | 3 sites (Créteil and 2 other locations) |
| Trial ID | NCT06050369 on ClinicalTrials.gov |
What this trial studies
This study aims to objectively distinguish between compulsions associated with obsessive-compulsive disorder (OCD) and tics related to Gilles de la Tourette syndrome (GTS) by identifying specific electrophysiological and accelerometric markers. Patients aged 15 to 65 with OCD and/or GTS will be recruited, and their brain activity will be recorded using high-density EEG in a laboratory setting and portable EEG at home while performing tasks. The goal is to enhance treatment selection by providing clear biomarkers for these repetitive behaviors.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 15 to 65 who have been diagnosed with OCD and/or GTS.
Not a fit: Patients with other psychiatric or neurological disorders, or those unable to provide informed consent, will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate diagnoses and tailored treatments for patients with OCD and tic disorders.
How similar studies have performed: While the approach of using electrophysiological markers is promising, it is relatively novel and has not been extensively tested in this specific context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * To be more of 15 years old or less than 65 years old * To suffer from OCD and/or GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted) * To be registered to the french social security (or something equivalent) * To give written consent to participate to the research * To have contraception for women participants (or to not have any sexual activity) Exclusion Criteria: * Patients with any other psychiatric disorders than those mentioned in the inclusion criteria * Patients with any other neurological disorder than GTS * Patients who are not able to take decisions for themselves * Pregnant women * Patients not allowed to get MRI due to contraindication * Patients not speaking french
Where this trial is running
Créteil and 2 other locations
- Hôpital Albert Chenevier — Créteil, France (RECRUITING)
- Hôpital Henri Mondor — Créteil, France (RECRUITING)
- Hôpital Pitié Salpêtrière — Paris, France (RECRUITING)
Study contacts
- Principal investigator: Luc MALLET, MD — Assistance Publique - Hôpitaux de Paris
- Study coordinator: Luc MALLET, MD
- Email: luc.mallet@inserm.fr
- Phone: +33157274000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: OCD, Tic Disorders, Gilles de la Tourette Syndrome, Electrophysiology, Electroencephalogram, EEG, Accelerometer, Biomarker