Characterizing Monocytes in Blood Disorders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on the functional and phenotypic characterization of monocytes in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs), including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. It aims to understand the role of monocytes and macrophages in the pathogenesis of these disorders, which are characterized by excessive production of myeloid cells due to specific genetic mutations. By analyzing monocyte signatures at diagnosis, the study seeks to uncover insights into the immune response and inflammation associated with MPNs. The findings could lead to a better understanding of the disease mechanisms and potential therapeutic targets.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of PV, ET, pre-myelofibrosis or primary myelofibrosis according to WHO 2022 criteria (including BOM for ET, premyelofibrosis and primary myelofibrosis)
* Patient who has not received treatment specific to hemopathy at the time of sampling
* Obtaining the signature of consent to participate in the study
* Patient having consented to be included in the "Malignant Hemopathy" collection of Angers University Hospital and in FIMBANK database

Exclusion Criteria:

* Person not affiliated to a social security scheme or beneficiary of such a scheme
* Patient with another hemopathy or another active cancer at the time of diagnosis
* Minor patient at diagnosis (\< 18 years old)
* Patient not capable or without agreement from the guardian or legal representative

Where it's running

• GOUBAND Agathe
  Angers, Maine et Loire, France Recruiting
• BESCOND Charles
  Cholet, Maine et Loire, France Not yet recruiting
• TRUCHAN-GRACZYK Malgorzata
  Saumur, Maine et Loire, France Not yet recruiting

Study contacts

• Principal investigator: Agathe GOUBAND, PharmD — University Hospital
• Study coordinator: Agathe GOUBAND, PharmD
• Email: Agathe.Gouband@chu-angers.fr
• Phone: 02 41 35 55 96

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.