Characterizing infections in the eye using advanced sequencing techniques
Official title: Total Infectome Characterization of Eye Infections: a Metagenomic Sequencing Based Observational Study
Run by Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · NCT06775808 · Data updated 2026-11-12
This study is trying to understand the different germs that cause eye infections by analyzing samples from people with conditions like pink eye and other serious infections.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | December 25, 2024 |
| Main results expected | October 30, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | July 17, 2025 |
| Trial ID | NCT06775808 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients diagnosed with one or more types of eye infections who can provide biological samples.
✕Probably not a fit
Patients without clinically surplus specimens or those not diagnosed with eye infections may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to investigate the total infectome of eye infections through metagenomic sequencing. It focuses on various types of eye infections, including acute conjunctivitis, keratitis, uveitis, and endophthalmitis, diagnosed by experienced ophthalmologists. Participants will provide biological samples, such as conjunctival swabs or intraocular fluid, which will be analyzed using the Illumina NovaSeq X Plus platform. Clinical information will also be collected from electronic medical records to support the analysis.
Why it matters
Potential benefit: If successful, this study could enhance the understanding and diagnosis of eye infections, leading to improved patient outcomes.
How similar studies have gone: While the approach of using metagenomic sequencing for pathogen surveillance is gaining traction, this specific application to eye infections is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with a clinical diagnosis of one or more types of eye infections (including acute conjunctivitis, keratitis, uveitis, and endophthalmitis). 2. Biological samples has been collected for clinical microbiological examination, or consented to participate in this study. Exclusion Criteria: 1\. Patients who have no historically clinical surplus specimens.
Where it's running
-
Shanghai General Hospital
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Mei Kang, MPH
- Email: mei.kang@shgh.cn
- Phone: 021-36126064
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AI analysis of ECGs to detect structural heart disease
This project will test whether AI can read traditional and wearable ECGs to find undiagnosed valve disease, pulmonary hypertension, and heart failure in adults.
-
Heart failure with preserved ejection fraction in people with COPD: clinical course and prognosis
This project will see how often HFpEF appears in people aged 50–70 hospitalized with COPD and whether having HFpEF changes their symptoms, exercise capacity, and prognosis.
-
Sonrotoclax plus azacitidine in high-risk MDS with increased blasts-2
This study tests whether adding sonrotoclax to azacitidine can help people with newly diagnosed high-risk MDS with increased blasts-2 see better disease control and tolerable safety.
-
Acupuncture to Improve Sleep and Reduce Pain After Lung Cancer Surgery (VATS)
This trial tests whether acupuncture given around surgery can improve sleep and lessen chronic pain for adults undergoing video-assisted thoracoscopic lung cancer removal.
-
STN-targeted non-invasive brain stimulation for Parkinson’s symptoms
A non-invasive procedure called tTIS is tested in people with Parkinson’s to see if it helps motor and non-motor symptoms.
-
Nimotuzumab plus Immunotherapy and Chemotherapy before surgery for locally advanced head and neck cancer
This phase 2 trial tests whether adding nimotuzumab to immunotherapy and chemotherapy before surgery helps people with locally advanced head and neck squamous cell carcinoma.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.