Changing infusion lines every 4 days versus every 7 days to prevent catheter infections in the ICU

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial enrolls adult ICU patients who have a central venous catheter placed by venipuncture within the past 72 hours and are expected to need it for at least 7 days. Participants are assigned to have infusion sets changed either every 4 days or every 7 days and are followed for catheter-related infections and bloodstream infection rates. The protocol keeps standard insertion and handling precautions the same for both arms and records nursing workload and device-related complications. Safety monitoring will capture any suspected catheter-related infections that require device removal or additional treatment.

Why it matters

Who can join: the full rules

Inclusion criteria

* Adult patient
* Any ICU patient with a central venous catheter (inserted by venipuncture) in place for less than 72 hours and with an expected dwell time of at least 7 days
* Patient affiliated with or covered by a social security system
* Patient who has given verbal consent or written consent from a third party or in the event that the patient is unable to give consent.

Exclusion Criteria

* Patient with a documented bloodstream infection at the time of inclusion
* Patient whose central venous catheter has been in place for more than 72 hours
* Patient with suspected catheter-related infection
* Patient whose study catheter was inserted using a guidewire exchange
* Patient previously enrolled in the study during the same ICU stay
* Patient whose condition, according to the clinician, does not allow safe placement of a central venous catheter, such as:

  * Allergy to catheter material
  * Confirmed deep vein thrombosis at the time of insertion
  * Inflammatory skin disorder at the insertion site
* Patient admitted for extensive burns
* Inadequate understanding of the French language
* Pregnant, breastfeeding, or postpartum woman
* Person deprived of liberty by judicial or administrative decision
* Person receiving involuntary psychiatric care
* Person under legal guardianship or other legal protection measure

Where it's running

• Angers University Hospital
  Angers, France Recruiting
• La Réunion University Hospital
  Saint-Pierre, La Réunion, France Not yet recruiting
• Albi Hospital
  Albi, France Not yet recruiting
• Belfort Hospital
  Belfort, France Not yet recruiting
• Bourges Hospital
  Bourges, France Not yet recruiting
• Caen University Hospital
  Caen, France Not yet recruiting

Study contacts

• Principal investigator: Carole Haubertin — University Hospital, Angers
• Study coordinator: Carole Haubertin
• Email: Carole.Haubertin@chu-angers.fr
• Phone: +332 41 35 40 82

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.