Cessation of alcohol and smoking to prevent acute pancreatitis recurrence

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of a lifestyle intervention aimed at preventing the recurrence of acute pancreatitis by promoting the cessation of alcohol consumption and smoking. It includes a randomized controlled trial and a cohort analysis to assess the impact of these lifestyle changes on patients hospitalized with alcohol-induced pancreatitis. Participants will receive standard cessation interventions and will be monitored for changes in motivation, addiction, quality of life, and socioeconomic status over time. Laboratory tests and biomarker measurements will also be conducted to evaluate the intervention's efficacy.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Patient hospitalized with alcohol-induced AP (defined by the revised Atlanta criteria 38)
* Every day smoker (defined as an adult patient who smoked at least 100 cigarettes in his or her lifetime, and now smokes on a daily basis; as per the CDC definition), with at least 1-year history of smoking
* Aged 18-80 years
* Provided written informed consent
* Willing to participate in the intervention in every three months

Exclusion criteria:

* Possible etiologies for AP other than alcohol (eg. gallstone-related, hypertriglyceridemia above 11.5 mM 40-42, hypercalcemia, viral infection) if the etiological cannot be terminated during the index admission (lack of same admission cholecystectomy, familiar hypertrygliceridemia) and cases with combined etiological factors will be excluded
* Untreated, decompensated or severe mMajor psychiatric illnesses (e.g. schizophrenia, bipolar disorder, dementia)
* Currently taking part in a smoking cessation program
* Undergoing active or palliative treatment for malignancy
* Pregnancy, breastfeeding
* Life expectancy is less than two years
* Didn't agreed to participate
* Other

Where it's running

• Institute for Translational Medicine, University of Pécs
  Pécs, Hungary Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.