Cervical tsDCS for improving hand and arm function after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates the facilitatory effects of cervical tsDCS on upper-limb motor responses in adults who recently had a stroke. Participants with mild-to-moderate arm weakness will receive tsDCS in addition to usual care to see if it improves strength, dexterity, and daily-living function. The trial includes an ischemic or hemorrhagic stroke window of up to 30 days post-onset and compares outcomes in adults with residual upper-limb function. A healthy control group will be enrolled to help interpret physiological responses. Safety and tolerability of tsDCS will also be monitored.

Why it matters

Who can join: the full rules

Group Stroke:

Inclusion criteria:

1. age over 18 years;
2. first ischemic/hemorrhagic stroke (within 30 days of onset);
3. mild-to-moderate stroke (NIHSS scale score\<16).
4. residual function of the upper limb, assessed by the following scales: - MRC of the distal muscles of the upper limb: score between 2 and 4; - NHISS (items 5A and 5B): score between 1 and 3;
5. ability to give informed consent and understand instructions.

Exclusion criteria:

1. severe spasticity (Ashworth Scale score \> 2);
2. severe aphasia;
3. severe neglect;
4. history of disabling neurological disease;
5. history of epilepsy;
6. significant comorbidities;
7. contraindications to tsDCS.

Healthy Group:

Inclusion criteria:

1. age over 18 years;
2. equalized in age with the patient group.

Exclusion criteria:

1. history of stroke progress;
2. history of severe neurological disease.

Where it's running

• IRCCS San Raffaele Roma
  Roma, Rm, Italy Recruiting
• IRCCS San Raffaele Roma
  Rome, Rome, Italy Not yet recruiting

Study contacts

• Study coordinator: Fabrizio Vecchio
• Email: fabrizio.vecchio@sanraffaele.it
• Phone: 3478031201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.