Central venous catheter placement with bedside ECG guidance and thoracic ultrasound

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center randomized feasibility trial compares standard ultrasound-guided CVC insertion with the addition of intracavity ECG tip confirmation and thoracic POCUS for pneumothorax detection. Eligible adults requiring internal jugular CVC placement are randomized to either the standard approach (ultrasound guidance plus post-procedure X-ray) or the intervention (ultrasound guidance plus IC-ECG tip confirmation and thoracic POCUS). All participants receive a post-procedure chest X-ray for comparison. The study aims to determine if bedside IC-ECG and POCUS can streamline verification and reduce imaging needs without compromising safety. Outcomes focus on feasibility, accuracy of tip location, detection of pneumothorax, and workflow implications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult (aged ≥ 18 years)
* Admitted, or planned for admission, to critical care
* Requiring central venous catheter insertion as a part of their usual care
* Suitable for both right or left internal jugular vein insertion

Exclusion Criteria:

* Previously randomised into CVC-TIP
* Atrial fibrillation on 12-lead ECG
* Cardiovascular instability, defined as
* Noradrenaline dose \> 0.5mcg/kg/min
* Rapidly escalating doses of vasopressors / inotropes
* Difficulty in obtaining thoracic ultrasound images due to either
* Weight \> 120kg
* Existing pneumothorax (either side)
* Subcutaneous emphysema
* Wounds / dressing over anterior chest wall
* Existing pacemaker
* Non-English speaking participants
* Death perceived as imminent
* Any other reason as determined by treating clinician

Where it's running

• York and Scarborough Teaching Hospitals NHS Foundation Trust
  York, North Yorkshire, United Kingdom Recruiting

Study contacts

• Principal investigator: Andrew Chamberlain, MBChB — York Teaching Hospitals NHS Foundation Trust
• Study coordinator: Andrew Chamberlain, MBChB
• Email: andrew.chamberlain8@nhs.net
• Phone: +441904 631313

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.