Cellular markers for non-tuberculous mycobacterial infection in adults with cystic fibrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter case-control study uses an Interferon-Gamma Release Assay (IGRA) to measure circulating T-cell IFNγ responses to NTM antigens in adults with cystic fibrosis drawn from the CIMeNT cohort. Participants are grouped as cases with positive serologic or microbiologic evidence of NTM and controls without such evidence, and blood samples are collected during a scheduled visit. The study aims to characterize a dynamic immune signature associated with NTM presence that could complement current clinical, radiological, and microbiological criteria. Sites include CHU de Montpellier and Hôpital Cochin, with coordination by the University Hospital Montpellier and collaborators including the Cystic Fibrosis Foundation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient ≥18 years
* Patient previously included in the CIMeNT study
* Patient with a confirmed diagnosis of cystic fibrosis regardless of CFTR genotype
* Patient affiliated to the social security system
* Patient registered in the French Cystic Fibrosis Registry
* Adult patient capable of spontaneous expectoration or after induction

Exclusion Criteria:

* Lung transplant patients
* Person placed under judicial protection
* Pregnant and breastfeeding women

Where it's running

• CHU de Montpellier - Hôpital Arnaud de Villeneuve
  Montpellier, France Recruiting

Study contacts

• Principal investigator: Raphael CHIRON, MD — Hôpital Arnaud de Villeneuve
• Study coordinator: Raphael CHIRON, MD
• Email: r-chiron@chu-montpellier.fr
• Phone: 0467336115

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Registry to collect data on mycobacterial infections in Austria

  This study is collecting information from patients in Austria with mycobacterial infections to see how their treatment goes and what factors might affect their recovery.

  Recruiting at 3 sites Ludwig Boltzmann Institute for Lung Health · Vienna and 2 other locations · NCT06522347

• Identifying new biological markers for lung disease in cystic fibrosis patients

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  Recruiting Ospedale San Raffaele · Milan, MI · NCT06413459

• Creating a database for patients with bronchiectasis and NTM in Canada

  This study is creating a database to gather information from adults with bronchiectasis and NTM to help improve care and understanding of these conditions.

  Recruiting University of Calgary · Calgary, Alberta · NCT06144996

• Using a daily symptom diary to monitor NTM lung infections

  This project will test whether a daily symptom diary can track disease course in adults with pulmonary nontuberculous mycobacterial (NTM) infections.

  Recruiting Research Center Borstel · Freiburg im Breisgau, Baden-Wurttemberg and 2 other locations · NCT07131774

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.