CD38-targeted PET/CT for detecting Multiple Myeloma lesions compared with FDG PET/CT
Official title: Clinical Investigation of CD38-Targeted Molecular Imaging Probes in Multiple Myeloma
Run by Guilin Medical University, China · NCT07782944 · Data updated 2026-11-12
This study tests a CD38-targeted PET/CT scan to see if it detects multiple myeloma lesions as well or better than the standard FDG PET/CT.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Guilin Medical University, China Academic / other |
| Locations | 1 site (Guilin, Guangxi) |
| Status | Recruiting |
| Started | July 7, 2026 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | August 24, 2026 |
| Trial ID | NCT07782944 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with newly diagnosed, highly suspected recurrence, or known metastases of multiple myeloma who are scheduled for both CD38 PET/CT and FDG PET/CT imaging.
✕Probably not a fit
Patients whose disease does not express CD38 or who do not have lesions detectable by CD38 PET/CT may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers compare a CD38-targeted PET/CT imaging method to the usual FDG PET/CT in adults with multiple myeloma or suspected recurrence. The study uses concurrent imaging to quantify tumor uptake and count lesions, then analyzes diagnostic accuracy against standard imaging. It is noninvasive and focuses on imaging performance rather than therapy. Enrollment includes adults requiring both imaging modalities, with analysis based on SUVmax and lesion counts.
Why it matters
Potential benefit: If successful, CD38 PET/CT could improve lesion detection and help guide management for multiple myeloma.
How similar studies have gone: Previous work suggests CD38-targeted imaging is promising for multiple myeloma, but broader validation is needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (aged 18 years or older); * Patients with newly diagnosed, highly suspected recurrence or previously treated metastases of Multiple Myeloma (supporting evidence may include MRI, CT, tumor markers, and pathology report); * Patients who had scheduled both standard-of-care imaging (FDG PET/CT) and cd38 PET/CT scans; * Patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee. Exclusion Criteria: * The inability or unwillingness of the research participant or legal representative to provide written informed consent.
Where it's running
-
The First Affliated Hospital of Guilin Medical University
Guilin, Guangxi, China Recruiting
Study contacts
- Study coordinator: Xingyu Mu, M.D.
- Email: muxingyu1992@hotmail.com
- Phone: 86 13347631119
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.