cCTL plus immunotherapy for advanced gynecologic cancers

Inclusion Criteria:

1. Age between 18 and 75 years；
2. Histologically or cytologically confirmed diagnosis of advanced ovarian cancer, cervical cancer, endometrial cancer, or other gynecological malignancies;
3. Tumor patients with previous standard treatment failure, or those who refuse further chemotherapy, with a life expectancy of more than 3 months;
4. ECOG performance status of 0-2;
5. Patients of childbearing potential must use appropriate contraceptive methods (e.g., contraception or other methods of fertility control) before and during the trial;
6. Ability to understand the trial and have signed the informed consent form;
7. Ability to comply with the study protocol and follow-up procedures.

Exclusion Criteria:

1. Receipt of any form of immunotherapy within the past 3 months;
2. Required use of immunosuppressive agents;
3. Receipt of tumor chemotherapy, radiotherapy, or second-degree or higher surgery within the past month;
4. History of other cancers, except for in situ cervical cancer, treated squamous cell carcinoma, or bladder epithelial tumors (Ta and TIS), or other malignancies that have undergone radical treatment (at least 5 years prior to enrollment);
5. White blood cell count \< 3×10\^9/L, platelet count \< 80×10\^9/L;
6. AST and ALT \> 3× upper limit of normal (ULN), total bilirubin \> 2× ULN, for liver metastasis patients, AST and ALT \> 6× ULN;
7. Creatinine clearance \< 60 ml/min;
8. Coagulation dysfunction;
9. Active bacterial or fungal infections (≥ grade 2 of NCI-CTC, 3rd edition);
10. Positive for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) with peripheral blood HBV DNA \> 100 IU/mL; positive for hepatitis C antibody with peripheral blood HCV RNA positive; positive for HIV antibody; positive CMV DNA; positive for syphilis;
11. Diseases deemed inappropriate for enrollment by the investigator, including but not limited to severe liver, kidney, or metabolic diseases requiring drug treatment, uncontrolled coronary artery disease or asthma, uncontrolled cerebrovascular disease;
12. Meeting any of the following heart-related standards:

    * Screening heart ultrasound shows left ventricular ejection fraction (LVEF) \< 50%;
    * Screening ECG at rest shows QTcF \> 480 ms (female);
    * Resting ECG shows any significant clinical arrhythmia, conduction, or morphological abnormalities (e.g., complete left bundle branch block, 2nd-3rd degree atrioventricular block, PR interval \> 250 ms);
    * Presence of factors increasing the risk of QTc interval prolongation or arrhythmic events, such as heart failure, hypokalemia, hypomagnesemia, congenital long QT syndrome, family history of long QT syndrome, or known medications that prolong QT intervals;
13. Pregnant or breastfeeding women; women of childbearing potential must test negative for pregnancy within 7 days prior to enrollment;
14. Drug abuse, clinical, psychological, or social factors that impair informed consent or study implementation；
15. Known allergy to the study drug;
16. Participation in other clinical trials within 1 month before enrollment;
17. Inability to undergo apheresis or inability to establish peripheral venous access;
18. Any uncertain factor that may affect the safety or compliance of the patient;
19. Other conditions considered unsuitable for enrollment by the investigator.