Caval Aorta Index to Guide Fluid Therapy in Traumatic Brain Injury
Official title: Efficacy of Caval Aorta Index for Fluid Optimization in Critically Ill Patients With Traumatic Brain Injury
Run by Mansoura University · NCT06940258 · Data updated 2026-11-12
A simple ultrasound test of the caval aorta index is used to guide fluid dosing in people with traumatic brain injury to help prevent secondary brain injury.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 92 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | June 1, 2025 |
| Main results expected | December 30, 2027 |
| Study ends | August 30, 2028 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT06940258 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with traumatic brain injury confirmed by CT and a Glasgow Coma Scale of 4 or higher, treated at Mansoura University Hospitals.
✕Probably not a fit
Patients with contraindications to ultrasound or those not meeting inclusion criteria may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study uses the caval aorta index, an ultrasound measurement of the IVC/aorta diameter ratio, to tailor fluid management in critically ill TBI patients. Participants are allocated to either fluid management guided by the caval aorta index or a standard control approach. The goal is to optimize cerebral perfusion and avoid hypotension or fluid overload that could worsen outcomes. The trial focuses on adults with TBI diagnosed by CT and a Glasgow Coma Scale of 4 or higher, treated at Mansoura University Hospitals. Ultrasound assessment is designed to be feasible by clinicians without specialized sonography training.
Why it matters
Potential benefit: If successful, the approach could improve fluid management and reduce secondary brain injury in TBI.
How similar studies have gone: Previous work has explored ultrasound-based volume status assessment, but applying the caval aorta index to guide TBI fluid therapy is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Traumatic brain injury diagnosed by computed tomography scan Glasgow coma score ≥ 4 Exclusion Criteria: Inability to get consent. Pregnant and lactating women Traumatic subarachnoid hemorrhage Spinal cord injury Increased intra-abdominal pressure Abdominal aortic aneurysm Inferior vena cava (IVC) thrombus Portal hypertension Acute corpulmonale Congestive heart failure chronic hemodialysis Surgical intervention other than neurological one within the first 7 days Mechanical ventilation need during first 7 days Cardiac arrest during the first 7 days
Where it's running
-
Mansoura University Hospitals
Al Mansurah, Egypt Recruiting
Study contacts
- Study coordinator: Maha Ahmed Abozeid, Professor
- Email: mahazed@yahoo.com
- Phone: 02-01019216192
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.