Cardiovascular outcomes after hematopoietic stem cell transplantation
Official title: Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation (CORE-HCT): A Prospective Multicenter Observational Study
Run by Peking University People's Hospital · NCT07349498 · Data updated 2026-11-12
We will collect clinical, laboratory, and treatment data from people who had hematopoietic stem cell transplants to see if certain factors are linked to heart and blood vessel problems after transplant.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 10000 (estimated) |
| Sponsor | Peking University People's Hospital Academic / other |
| Locations | 16 sites (Beijing, Beijing Municipality and 15 other locations) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | June 30, 2036 |
| Study ends | December 31, 2036 |
| Registry record updated | January 16, 2026 |
| Trial ID | NCT07349498 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients who undergo hematopoietic cell transplantation at any participating center and agree to prospective data collection are eligible to join.
✕Probably not a fit
People who did not receive a transplant at a participating site, who withdraw consent, or whose other medical conditions make data interpretation unreliable are unlikely to gain direct benefit from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, multicenter observational cohort of patients who received hematopoietic cell transplantation at participating centers. Investigators will enroll transplant recipients and collect clinical characteristics, laboratory profiles, management measures, and follow-up data on cardiovascular events. Data will be gathered prospectively across several major tertiary hospitals and pooled for analysis of incidence and risk factors. The aim is to characterize post-transplant cardiovascular outcomes and drivers of risk to inform future care strategies.
Why it matters
Potential benefit: If successful, the findings could help identify patients at higher risk of cardiovascular complications after transplant so clinicians can tailor monitoring and prevention.
How similar studies have gone: Previous observational cohorts have documented increased cardiovascular risk after hematopoietic cell transplantation and identified some risk factors, but large prospective multicenter efforts to refine risk prediction have been limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who undergo hematopoietic cell transplantation at any of the participating medical centers. Exclusion Criteria: * Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data. * Patient request to withdraw from the study.
Where it's running
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Chinese PLA General Hospital
Beijing, Beijing Municipality, China Recruiting -
Peking University First Hospital
Beijing, Beijing Municipality, China Recruiting -
Peking University People's Hospital
Beijing, Beijing Municipality, China Recruiting -
Peking University Third Hospital
Beijing, Beijing Municipality, China Recruiting -
Xinqiao hospital of the third military medical university
Chongqing, Chongqing Municipality, China Recruiting -
Sun Yat-sen University Cancer Center, Sun Yat-sen University
Guangzhou, Guangdong, China Recruiting
Show 10 more locations
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Peking University Shenzhen Hospital
Shenzhen, Guangdong, China Recruiting -
First Affiliated Hospital of Harbin Medical University
Harbin, Heilongjiang, China Recruiting -
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China Recruiting -
Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology
Wuhan, Hubei, China Recruiting -
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China Recruiting -
First Affiliated Hospital Xi'an Jiaotong University
Xi'an, Shaanxi, China Recruiting -
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China Recruiting -
Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)
Tianjin, Tianjin Municipality, China Recruiting -
First Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China Recruiting -
First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Study coordinator: Xiao Hui Zhang
- Email: zhangxh@bjmu.edu.cn
- Phone: 861088324577
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Population PK-guided ATG Dosing in Haploidentical Stem Cell Transplant
This trial tests a population PK-guided ATG dosing strategy in people undergoing haploidentical hematopoietic stem cell transplantation to see if it improves outcomes.
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Population PK-guided ATG Dosing in Haplo-HSCT
This study tests a population PK-guided dosing strategy for anti-thymocyte globulin (ATG) in adults and adolescents undergoing haploidentical stem cell transplantation to see if it can reduce GVHD while keeping relapse risk acceptable.
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Low-dose liposomal amphotericin B to prevent invasive fungal infections in neutropenic children
This study tests whether giving a fixed low dose of liposomal amphotericin B can prevent invasive fungal infections in children aged 3–17 who are severely neutropenic after hematopoietic stem cell transplantation or similar high-risk conditions.
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Personalized ATG dosing in unrelated donor stem cell transplants
This trial tests whether tailoring anti-thymocyte globulin dosing works better than standard fixed dosing in adults and adolescents receiving unrelated donor stem cell transplants.
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Hematologic cancer survivors after stem cell transplant try a personalized care plan
This study tests a personalized Survivorship Care Plan for people with hematologic cancer who have undergone a stem cell transplant to see if it’s feasible within the Italian health system.
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T-cell–guided letermovir stopping after allogeneic stem cell transplant
This tests whether using a CMV-specific T-cell blood test to decide when adult CMV-positive patients can stop letermovir after allogeneic stem cell transplant keeps them protected while avoiding unnecessary drug exposure.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.