Clinical trial Recruiting at 16 sites Observational

Cardiovascular outcomes after hematopoietic stem cell transplantation

Official title: Cardiovascular Outcomes and Risk Evaluation Among Recipients of Hematopoietic Stem Cell Transplantation (CORE-HCT): A Prospective Multicenter Observational Study

Run by Peking University People's Hospital · NCT07349498 · Data updated 2026-11-12

We will collect clinical, laboratory, and treatment data from people who had hematopoietic stem cell transplants to see if certain factors are linked to heart and blood vessel problems after transplant.

Quick facts

Study typeObservational
SexAll
Enrollment10000 (estimated)
SponsorPeking University People's Hospital
Academic / other
Locations16 sites (Beijing, Beijing Municipality and 15 other locations)
StatusRecruiting
StartedJanuary 1, 2026
Main results expectedJune 30, 2036
Study endsDecember 31, 2036
Registry record updatedJanuary 16, 2026
Trial IDNCT07349498 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Patients who undergo hematopoietic cell transplantation at any participating center and agree to prospective data collection are eligible to join.

Probably not a fit

People who did not receive a transplant at a participating site, who withdraw consent, or whose other medical conditions make data interpretation unreliable are unlikely to gain direct benefit from this project.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, multicenter observational cohort of patients who received hematopoietic cell transplantation at participating centers. Investigators will enroll transplant recipients and collect clinical characteristics, laboratory profiles, management measures, and follow-up data on cardiovascular events. Data will be gathered prospectively across several major tertiary hospitals and pooled for analysis of incidence and risk factors. The aim is to characterize post-transplant cardiovascular outcomes and drivers of risk to inform future care strategies.

Why it matters

Potential benefit: If successful, the findings could help identify patients at higher risk of cardiovascular complications after transplant so clinicians can tailor monitoring and prevention.

How similar studies have gone: Previous observational cohorts have documented increased cardiovascular risk after hematopoietic cell transplantation and identified some risk factors, but large prospective multicenter efforts to refine risk prediction have been limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients who undergo hematopoietic cell transplantation at any of the participating medical centers.

Exclusion Criteria:

* Any other conditions that, in the opinion of the investigator, can interfere with the interpretation of data.
* Patient request to withdraw from the study.

Where it's running

  • Chinese PLA General Hospital
    Beijing, Beijing Municipality, China
    Recruiting
  • Peking University First Hospital
    Beijing, Beijing Municipality, China
    Recruiting
  • Peking University People's Hospital
    Beijing, Beijing Municipality, China
    Recruiting
  • Peking University Third Hospital
    Beijing, Beijing Municipality, China
    Recruiting
  • Xinqiao hospital of the third military medical university
    Chongqing, Chongqing Municipality, China
    Recruiting
  • Sun Yat-sen University Cancer Center, Sun Yat-sen University
    Guangzhou, Guangdong, China
    Recruiting
Show 10 more locations
  • Peking University Shenzhen Hospital
    Shenzhen, Guangdong, China
    Recruiting
  • First Affiliated Hospital of Harbin Medical University
    Harbin, Heilongjiang, China
    Recruiting
  • The First Affiliated Hospital of Zhengzhou University
    Zhengzhou, Henan, China
    Recruiting
  • Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology
    Wuhan, Hubei, China
    Recruiting
  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
    Wuhan, Hubei, China
    Recruiting
  • First Affiliated Hospital Xi'an Jiaotong University
    Xi'an, Shaanxi, China
    Recruiting
  • Sichuan Provincial People's Hospital
    Chengdu, Sichuan, China
    Recruiting
  • Hematology Hospital of Chinese Academy of Medical Sciences (Hematology Research Center of Chinese Academy of Medical Sciences)
    Tianjin, Tianjin Municipality, China
    Recruiting
  • First Affiliated Hospital of Xinjiang Medical University
    Ürümqi, Xinjiang, China
    Recruiting
  • First Affiliated Hospital of Zhejiang University
    Hangzhou, Zhejiang, China
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

  • Population PK-guided ATG Dosing in Haploidentical Stem Cell Transplant

    This trial tests a population PK-guided ATG dosing strategy in people undergoing haploidentical hematopoietic stem cell transplantation to see if it improves outcomes.

    Recruiting Phase 3 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07862127

  • Population PK-guided ATG Dosing in Haplo-HSCT

    This study tests a population PK-guided dosing strategy for anti-thymocyte globulin (ATG) in adults and adolescents undergoing haploidentical stem cell transplantation to see if it can reduce GVHD while keeping relapse risk acceptable.

    Recruiting Phase 2 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07791576

  • Low-dose liposomal amphotericin B to prevent invasive fungal infections in neutropenic children

    This study tests whether giving a fixed low dose of liposomal amphotericin B can prevent invasive fungal infections in children aged 3–17 who are severely neutropenic after hematopoietic stem cell transplantation or similar high-risk conditions.

    Recruiting Haikou Affiliated Hospital of Central South University Xiangya School of Medicine · Haikou, Hainan · NCT07725263

  • Personalized ATG dosing in unrelated donor stem cell transplants

    This trial tests whether tailoring anti-thymocyte globulin dosing works better than standard fixed dosing in adults and adolescents receiving unrelated donor stem cell transplants.

    Recruiting Phase 4 Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT07648992

  • Hematologic cancer survivors after stem cell transplant try a personalized care plan

    This study tests a personalized Survivorship Care Plan for people with hematologic cancer who have undergone a stem cell transplant to see if it’s feasible within the Italian health system.

    Recruiting Azienda USL Reggio Emilia - IRCCS · Reggio Emilia · NCT07579065

  • T-cell–guided letermovir stopping after allogeneic stem cell transplant

    This tests whether using a CMV-specific T-cell blood test to decide when adult CMV-positive patients can stop letermovir after allogeneic stem cell transplant keeps them protected while avoiding unnecessary drug exposure.

    Recruiting Phase 4 Union Hospital, Tongji Medical College, Huazhong University of Science and Technology · Beijing, Beijing Municipality and 11 other locations · NCT07569653

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.