Cardiac MRI for risk prediction in non-dilated left ventricular cardiomyopathy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective observational cohort drawn from patients diagnosed with non-dilated left ventricular cardiomyopathy who underwent cardiac magnetic resonance (CMR) at a single tertiary center. CMR measures including left ventricular ejection fraction, late gadolinium enhancement patterns, myocardial strain, and the extent of fibrosis or fatty replacement will be extracted from imaging records. Patients meeting indexed LVEDV thresholds with LVEF <50% and/or non-ischemic scar/fat on CMR will be included and followed using chart review for clinical outcomes. The primary outcome is a composite of major adverse cardiovascular events, such as all-cause mortality and heart transplantation, with statistical modeling used to identify imaging predictors and other risk factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 16 years;
* indexed left ventricular end-diastolic volume (LVEDVi) \<96 mL/m2 in females and \<105 mL/m2 in males at baseline cardiac magnetic resonance (CMR);
* either left ventricular ejection fraction (LVEF) \<50% and/or non-ischemic left ventricular (LV) scar/fatty replacement at baseline cardiac magnetic resonance.

Exclusion Criteria:

* lacked enhanced CMR images due to contraindications for receiving gadolinium contrast, such as severe renal disease;
* ischemic heart disease, defined as stenosis of \>50% in a major epicardial coronary artery underwent coronary computed tomography angiography or coronary angiography, ischemic late gadolinium enhancement (LGE) pattern on CMR indicating prior infarction, or prior coronary revascularization;
* abnormal loading conditions, defined as moderate to severe valvular heart diseases, congenital heart diseases, uncontrolled hypertension;
* systemic rheumatologic diseases or sarcoidosis;
* diagnostic criteria for other cardiomyopathies according to the European Society of Cardiology (ESC) definitions.

Where it's running

• Chinese Academy of Medical Sciences and Peking Union Medical College, Fuwai Hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Lu Minjie PHD
• Email: coolkan@163.com
• Phone: +86-10-88396941

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.