Cardiac CT imaging of coronary arteries and heart muscle after a heart attack
Multimodal Cardiac CT-Derived High-Risk Coronary and Myocardial Features for Predicting Adverse Outcomes After PCI in Patients With Acute Myocardial Infarction: A Multicenter Prospective Cohort Study
This will test whether adding a cardiac CT scan soon after PCI can help predict which adults who recently had a heart attack are at higher risk for later problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nanjing First Hospital, Nanjing Medical University Academic / other |
| Locations | 2 sites (Nanjing, Jiangsu and 1 other locations) |
| Trial ID | NCT07537296 on ClinicalTrials.gov |
What this trial studies
This is an observational study of adults who had an acute myocardial infarction and underwent PCI; participants will receive a multimodal cardiac CT within seven days after PCI alongside routine echocardiographic follow-up and telephone monitoring. The protocol excludes patients with severe renal dysfunction, iodine contrast allergy, prior CABG, prior MI or heart failure, or other conditions that would prevent good imaging. Imaging and clinical follow-up data will be used to relate CT findings to subsequent remodeling and cardiovascular events. The goal is to develop better, more accessible risk-stratification tools after revascularization.
Who should consider this trial
Good fit: Adults aged 18 or older who had a STEMI or NSTEMI within the past four weeks, were treated with PCI, are hemodynamically stable, and can undergo cardiac CT and telephone follow-up are ideal candidates.
Not a fit: Patients with eGFR <30 mL/min/1.73 m², iodine contrast allergy, prior CABG, prior MI or heart failure, severe arrhythmias, poor image quality, or expected survival under six months are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, the approach could improve prediction of adverse events after a heart attack and help tailor follow-up care to reduce complications.
How similar studies have performed: Echocardiography and cardiac MRI have established prognostic roles after AMI and small studies suggest cardiac CT may add prognostic information, but larger prospective validation is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * AMI within the previous 4 weeks, including STEMI or NSTEMI * PCI performed for ACS culprit lesion according to current guidelines * Hemodynamically stable * Willingness to undergo multimodal cardiac CT within 7 days after PCI * Willingness to participate in telephone follow-up Exclusion Criteria: * Contraindications to cardiac CT (eGFR \<30 mL/min/1.73 m² or iodine contrast allergy) * Previous coronary artery bypass graft surgery (CABG) * History of heart failure or previous myocardial infarction * Severe arrhythmia or structural heart disease * Poor image quality or missing CT data * Expected survival \<6 months
Where this trial is running
Nanjing, Jiangsu and 1 other locations
- Nanjing First Hospital, Nanjing Medical University, 68 Changle road, Qinhuai District — Nanjing, Jiangsu, China (Recruiting)
- Nanjing First Hospital, Nanjing Medical University, 68 Changle road, Qinhuai District — Nanjing, Jiangsu, China (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.