Capillary refill time and perfusion index relationship in critically ill adults
Correlation Between Capillary Refilling tIme and Perfusion Index in Critically Ill Patients
This research will test whether the perfusion index from a pulse oximeter can match capillary refill time for monitoring tissue perfusion in adults recently admitted to intensive care with shock or unstable circulation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 2 sites (Bron and 1 other locations) |
| Trial ID | NCT07555041 on ClinicalTrials.gov |
What this trial studies
This observational study will collect paired capillary refill time (CRT) measurements and perfusion index (PI) readings from a pulse oximeter in adult patients within 24 hours of ICU admission or onset of hemodynamic instability. Measurements will be performed using standard brief skin pressure for CRT and routine pulse-oximeter sensors for PI to compare concordance across clinical states. Patients with morphological barriers to CRT or PI measurement, those under legal protection, or lacking social security coverage are excluded. The goal is to determine whether PI provides a faster, more standardized, and less staff-intensive indicator of peripheral perfusion than repeated bedside CRT checks.
Who should consider this trial
Good fit: Adults admitted to participating ICUs within 24 hours or within 24 hours of hemodynamic instability requiring fluids or vasopressors, who can consent and have no anatomical or skin issues preventing CRT or PI measurement.
Not a fit: Patients who are pediatric, under legal guardianship, lack social security coverage, or have morphological skin or limb abnormalities that prevent accurate CRT or pulse oximetry readings are unlikely to benefit.
Why it matters
Potential benefit: If PI reliably tracks CRT, clinicians could use pulse oximeter–derived PI for quicker, continuous perfusion monitoring with less staff time.
How similar studies have performed: Previous small studies have reported mixed but promising correlations between perfusion index and CRT, though findings are not yet definitive or standardized.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria : * Adult patient. * Admission within the previous 24 hours, or within 24 hours of the onset of a hemodynamic instability criterion (requirement for vasopressors or fluid resuscitation). * Absence of patient objection. Exclusion criteria : * Legal guardianship, curatorship, or judicial protection. * No social security coverage. * Morphological abnormalities preventing CRT and IP measurements.
Where this trial is running
Bron and 1 other locations
- Service de Réanimation cardio-vasculaire et thoracique, Hôpital Cardiologique louis Pradel, Hospices Civils de Lyon — Bron, France (Recruiting)
- Service de Médecine Intensive-Réanimation, Hôpital Édouard Herriot, Hospices Civils de Lyon — Lyon, France (Recruiting)
Study contacts
- Study coordinator: Neven STEVIC, MD
- Email: neven.stevic@chu-lyon.fr
- Phone: 4 72 11 28 62
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.