Cannabis and Sleep: How Marijuana Affects Sleep Duration and Quality
Official title: Longitudinal Reciprocal Relationships Between Cannabis Use, Sleep, and the HPA-axis (CaSS)
Run by Oregon Health and Science University · NCT06982950 · Data updated 2026-11-12
This study tests how cannabis use influences sleep duration and quality in adults over a 21-day monitoring period.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 21 Years to 29 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Oregon Health and Science University Academic / other |
| Locations | 1 site (Portland, Oregon) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | June 30, 2030 |
| Study ends | June 30, 2032 |
| Registry record updated | October 19, 2026 |
| Trial ID | NCT06982950 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults fluent in English, BMI between 18.5 and 40 kg/m2, not engaged in shift work recently, and without major chronic or psychiatric conditions as listed.
✕Probably not a fit
Individuals with certain unmanaged health conditions, heavy alcohol or illicit drug use, or significant psychiatric illness may not experience sleep-related benefits from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants undergo an initial sleep lab night with full polysomnography to establish a baseline, followed by an 8-hour sleep protocol and multiple days of ecological momentary assessments and actigraphy to monitor sleep and cannabis-use patterns in real life. After familiarization, participants are randomized to different sleep-duration protocols while researchers collect data on cannabis use frequency, amount, and method, along with stress and sleep outcomes. The study uses a combination of lab-based sleep testing, wearable movement data, and frequent surveys to understand the relationship between cannabis use, sleep, and stress in everyday settings. The design aims to characterize how cannabis-related behaviors relate to sleep parameters in a real-world environment.
Why it matters
Potential benefit: If successful, findings could clarify how cannabis use might influence sleep patterns and daytime functioning, potentially guiding personalized sleep recommendations.
How similar studies have gone: Prior research using polysomnography and ecological momentary assessment has shown detectable links between cannabis use and sleep, though results vary by protocol and population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * fluent in English * 18.5\<BMI\<40 kg/m2 * no shift work in the last 12 months * no travel across time zones in the last 2 months. Exclusion Criteria: * Chronic disease-Medical history/prior diagnosis of the following: * cardiometabolic disease (e.g., myocardial infarction, angina, diabetes) * essential hypertension * hepatic impairment * severe obstructive sleep apnea * restless legs syndrome * parasomnia * neurological disease (e.g., early onset dementia) * unstable psychiatric disorders (e.g., bipolar disorder, schizophrenia, major depression with suicidality). * Drug/Alcohol use criteria: * Illicit drugs apart from cannabis or related products are prohibitive. * Volunteers may consume caffeine, however, \>3 cups of coffee (or otherwise equivalent of \>300mg/day) is prohibitive. * Participants who consume \>14 alcoholic drinks/week and/or have a diagnosis (or history) of alcohol use disorder will be excluded (a toxicological urine screen will be conducted to verify reported non-use during the initial screening and on the day of admission to the in-laboratory portion of the study). * Use of prescription or over-the-counter medications or supplements that affect sleep are also exclusionary. * Contraceptives are required for women and will continue to be taken throughout the experiment. * Prior Shift Work: * Volunteers must have no history of working irregular day and night hours, regular night work, or rotating shift work for the 3 months prior to the study.
Where it's running
-
Ohsu
Portland, Oregon, United States Recruiting
Study contacts
- Study coordinator: Nicole Bowles, PhD
- Email: circadian@ohsu.edu
- Phone: 5034942541
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.