Can Cardiac Cycle Efficiency predict high-dose vasoactive-inotropic needs after open-heart surgery?

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center prospective observational study will analyze hemodynamic data collected from arterial lines at six perioperative time points after cardiopulmonary bypass. Cardiac Cycle Efficiency (CCE) is derived from arterial waveform analysis using MostCare Up and will be evaluated for its ability to predict a maximum VIS of 15 or higher within 24 hours postoperatively. The predictive performance will be assessed with ROC analysis, and associations with lactate levels, duration of mechanical ventilation, ICU/hospital stay, acute kidney injury, and in-hospital mortality will be explored. No additional procedures will be performed beyond routine care, and data come from standard arterial monitoring. The goal is to identify early markers of patients at risk for significant vasopressor/inotrope support.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* ASA physical status II-IV
* Elective coronary artery bypass grafting, valve surgery, or combined CABG and valve surgery with cardiopulmonary bypass
* Written informed consent

Exclusion Criteria:

* Emergency surgery
* Preoperative mechanical circulatory support (IABP, ECMO, Impella, etc.)
* Permanent pacemaker dependency
* Severe arrhythmia (uncontrolled atrial fibrillation, ventricular arrhythmia, etc.)
* Redo cardiac surgery
* Aortic dissection
* Pregnancy
* Unreliable arterial pressure waveform
* Need for IABP, ECMO, or temporary epicardial pacing during weaning from bypass or during surgery

Where it's running

• Bursa City Hospital
  Nilufer, Bursa, Turkey (Türkiye) Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.