Aminophylline versus furosemide for urine output after adult heart surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional comparison enrolls adults aged 18–65 undergoing elective cardiac surgery on cardiopulmonary bypass to compare the diuretic effects of aminophylline and furosemide. Eligible participants have BMI 20–40 and no end‑stage kidney disease, prior dialysis, or prior solid-organ transplant. The protocol administers one of the two diuretics perioperatively and monitors urine output, serum creatinine, and the incidence of cardiac surgery–associated acute kidney injury. The goal is to determine whether aminophylline reduces postoperative AKI frequency or better manages volume compared with a loop diuretic.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 18-65 years.
* Both sexes.
* All adult patients presenting for elective cardiac surgical procedures performed on cardiopulmonary bypass (Coronary artery bypass surgery, Cardiac valve repair and/or replacement, Repair of large septal defects, Repair and/or palliation of congenital heart defects, Transplantation, surgery of thoracic aneurysms.).
* Body mass index (BMI) ranged between 20 and 40 kg/m2.

Exclusion Criteria:

* Sensitivity or contraindication to Aminophylline or furosemide
* Stage-5 chronic kidney disease (CKD) \[Glomerular filtration rate (GFR) of less than 15 mL/min\].
* The presence of both factors (GFR less than 60 mL/min and albumin greater than 30 mg per gram of creatinine) along with abnormalities of kidney structure or function for greater than three months signifies chronic kidney disease.
* Recipients of dialysis before surgery.
* Recipients of solid-organ transplantation before surgery.
* Emergency cardiac surgical procedures (e.g. left main coronary artery bypass graft, stuck valves, etc).
* Patient refusal.

Where it's running

• Cairo University
  Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed M Hassan, MSc
• Email: ahm33hassan@gmail.com
• Phone: 00201033752020

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.