Buprenorphine via PCA vs oxycodone for pain after VATS
Official title: Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery - A Prospective, Randomized Clinical Trial
Run by Medical University of Silesia · NCT07434427 · Data updated 2026-11-12
This trial tests whether intravenous buprenorphine given through a patient-controlled pump provides better and safer pain relief than intravenous oxycodone after video-assisted thoracic surgery in adults.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | Medical University of Silesia Academic / other |
| Locations | 1 site (Zabrze, Silesian Voivodeship) |
| Status | Recruiting |
| Started | March 18, 2026 |
| Main results expected | May 2027 |
| Study ends | November 2027 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07434427 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-75 undergoing elective VATS, ASA I-III, expected to use a PCA postoperatively.
✕Probably not a fit
Patients with chronic opioid therapy, opioid hypersensitivity, or contraindications to buprenorphine/oxycodone may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind study compares intravenous buprenorphine PCA with oxycodone PCA for postoperative pain control after video-assisted thoracoscopic surgery (VATS). Adults aged 18-75 with ASA I-III undergoing elective VATS will be enrolled and randomized to receive one of the two opioids for PCA-based analgesia, with pain and safety outcomes tracked over the first 48 hours and beyond. Primary endpoints include pain control at rest and during mobilization and the incidence of respiratory or sedation-related adverse events; secondary endpoints assess other opioid-related side effects and longer-term pain trajectories. The trial will be conducted at Medical University of Silesia's Clinical Hospital No 1 in Zabrze with 200 participants, using a double-blind design and standardized analgesia protocols.
Why it matters
Potential benefit: If successful, buprenorphine PCA could provide effective pain relief with fewer respiratory complications after VATS.
How similar studies have gone: Past studies in opioid analgesia have shown varying results; this study uses a direct head-to-head, double-blind design to establish comparative safety and efficacy for buprenorphine in the PCA setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * qualification for elective thoracic surgery performed using the VATS technique, physical status ASA I-III, anticipated use of PCA in the postoperative period, patient's consent to participate in the study. Exclusion Criteria: * inability to provide informed consent, * hypersensitivity to opioids or study medications, * chronic opioid therapy, * previously diagnosed chronic pain, * chronic use of analgesic medications, * disorders of consciousness preventing appropriate use of the PCA pump, * severe renal or hepatic insufficiency, * pregnancy or breastfeeding, * clinically relevant drug interactions (rifampicin, carbamazepine, CYP3A4 inhibitors).
Where it's running
-
Clinical Hospital No 1
Zabrze, Silesian Voivodeship, Poland Recruiting
Study contacts
- Study coordinator: Justyna K Danel, Medical Doctor
- Email: justyna.danel@gmail.com
- Phone: +48 514 429 489
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.