Buffered lidocaine for myofascial pain: a comparison with lidocaine alone

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group, single-blind trial compares lidocaine alone to lidocaine buffered with sodium bicarbonate for trigger point injections in myofascial pain syndrome. Outcome measures include pain scores and functional assessments, with surface electromyography used to characterize muscle activity. Eligible participants are aged 16 to 70 with documented MPS and active trigger points, and follow-up visits monitor safety and response to treatment. The study aims to see if buffering lidocaine provides faster onset, less injection pain, and longer-lasting relief than lidocaine alone. Lead sponsorship is Cairo University, conducted at the Faculty of Dentistry in Cairo, with no listed collaborators.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Patients aged 16 to 70 years Clinical diagnosis of myofascial pain syndrome (MPS) Presence of active myofascial trigger points Pain duration ≥ 3 months Pain intensity ≥ 4 on the Visual Analog Scale (VAS) Trigger points located in accessible muscles No trigger point injection in the affected area within the past 3 months Ability and willingness to provide informed consent Willingness to comply with study procedures and follow-up visits

Exclusion Criteria:

Known allergy or hypersensitivity to lidocaine, sodium bicarbonate, or other amide-type local anesthetics Current use of anticoagulants or presence of bleeding disorders Local or systemic infection at or near the injection site History of fibromyalgia, cancer-related pain, or central pain syndromes Major psychiatric disorders (e.g., schizophrenia, severe depression) Recent trauma or surgery to the neck, shoulder, or back within the past 6 months Use of analgesics (e.g., NSAIDs, opioids) within 5 days prior to injection Severe systemic diseases (e.g., uncontrolled diabetes, liver failure, kidney failure, severe cardiovascular disease)

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Where it's running

• Faculty of Dentistry Cairo University
  Cairo, Cairo Governorate, Egypt Recruiting

Study contacts

• Principal investigator: ola mohamed Abdelfath — cairo university oral and maxillofacial surgery department
• Study coordinator: ola mohamed Abdelfatah, bachelor
• Email: ola.abdelfatah@dentistry.cu.edu.eg
• Phone: +201122789240

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.