Magnesium sulfate added to lidocaine for trigger point injections in myofascial pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a randomized trial, adults with clinically diagnosed Myofascial Pain Dysfunction Syndrome will be assigned to receive trigger point injections of either lidocaine 2% alone or lidocaine 2% combined with magnesium sulfate 10%. Injections will be given into identified active myofascial trigger points and pain during and after injection will be measured using a Visual Analog Scale (VAS). Muscle activity will be recorded with surface electromyography (sEMG) at specified time points during rest and contraction to compare muscle relaxation between groups. The study compares changes in pain scores and sEMG readings to determine whether magnesium sulfate provides additional analgesic or muscle-relaxing effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 and 70 years.
2. Clinical diagnosis of Myofascial Pain Dysfunction Syndrome (MPDS).
3. Presence of active myofascial trigger points in accessible muscles (e.g., masseter, temporalis, upper trapezius).
4. Pain duration ≥ 3 months.
5. Pain intensity ≥ 4 on the Visual Analog Scale (VAS).
6. Noprior trigger point injection in the affected area within the past 3 months.
7. Ability and willingness to provide informed consent.
8. Compliance with study visits and procedures

Exclusion Criteria:

1. Known allergy or hypersensitivity to Lidocaine, Magnesium Sulfate, or related agents.
2. Current use of anticoagulants or history of bleeding disorders.
3. Systemic or local infection at or near the injection site.
4. History of fibromyalgia, central pain syndromes, or cancer-related pain.
5. Major psychiatric illnesses (e.g., schizophrenia, severe depression).
6. Recent surgery or trauma to the head, neck, or upper back (\<6 months).
7. Use of analgesics (NSAIDs, opioids) within 5 days before intervention.
8. Severe systemic diseases:- Uncontrolled diabetes mellitus- Liver or kidney failure- Severe cardiovascular conditions.

Where it's running

• Faculty of oral and dental medicine, cairo university
  Giza, Giza Governorate, Egypt Recruiting

Study contacts

• Principal investigator: Maii E Abdelazeem, Bsc — Faculty of Oral & Dental Medicine, Cairo University
• Study coordinator: Maii E Abdelazeem, BSc
• Email: Maii.emad@dentistry.cu.edu.eg
• Phone: +20 1013988933

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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  A 60-person study tests whether focused shockwave therapy can reduce pain and improve function in adults with chronic neck and shoulder myofascial pain compared with a home exercise program.

  Recruiting Cishan Hospital, Ministry of Health and Welfare · Kaohsiung City · NCT07660523

• Tele-rehabilitation for rhomboid trigger points in myofascial pain syndrome

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• Reflex therapy and dry needling for jaw muscle and joint pain

  This trial will try adding dry needling to standard rehabilitation to see if adults with functional temporomandibular (jaw) pain get less pain, better jaw movement, and improved quality of life.

  Recruiting Palacky University · Olomouc · NCT07321483

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.