Brisk walking exercise for knee osteoarthritis and its effects on irisin levels
The Relationship Between Physical and Psychosocial Status and Irisin Level in Individuals With Knee Osteoarthritis Performing Brisk Walking Exercise
This study is testing if an 8-week brisk walking program can improve knee osteoarthritis symptoms and boost irisin levels, which might help with joint function and mood.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 46 (estimated) |
| Ages | 40 Years to 65 Years |
| Sex | All |
| Sponsor | Alanya Alaaddin Keykubat University Academic / other |
| Locations | 1 site (Karaman) |
| Trial ID | NCT06758388 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of an 8-week brisk walking exercise program on irisin levels and various physical and psychosocial parameters in individuals with knee osteoarthritis. Irisin is a myokine that may enhance joint function and improve mood by promoting bone density and reducing inflammation. Participants will engage in a home exercise program combined with brisk walking to assess changes in irisin levels and their correlation with improvements in physical and psychosocial health. The study aims to provide insights into the relationship between exercise, irisin, and knee osteoarthritis outcomes.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 40-65 with idiopathic knee osteoarthritis classified as stage 1-3 according to the Kellgren-Lawrence classification.
Not a fit: Patients with psychiatric diseases, uncontrolled cardiovascular conditions, or recent knee joint surgeries may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for knee osteoarthritis, enhancing patients' physical function and quality of life.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have indicated that exercise can positively influence irisin levels and related health outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with idiopathic knee OA * Stage 1-3 knee OA according to the Kellgren-Lawrence classification * Patients aged 40-65 * Patients agreeing to participate in the study * Patients having physical and cognitive ability to participate in the exercise program Exclusion Criteria: * History of depression and/or anxiety etc. psychiatric disease * Uncontrolled hypertension, uncontrolled heart rhythm disorders, history of hospitalization for cardiovascular reasons in the last 6 months * History of symptomatic pulmonary disease * Use of medication due to dyslipidemia and/or diabetes * Presence of acute inflammation or effusion in the knee joint * Presence of central or peripheral neurological disease that will cause loss of lower extremity muscle strength, sensation, and balance * Presence of a prosthetic joint in the knee and previous lower extremity surgery * Having received a physical therapy program in the last 6 months * Patients with severe visual or hearing impairment * Patients with severe peripheral vascular disorders * Presence of severe knee joint instability, ligament and meniscal damage * Being illiterate
Where this trial is running
Karaman
- Karaman Training and Research Hospital — Karaman, Turkey (Recruiting)
Study contacts
- Study coordinator: Ümmahani Kuş, Physiotherapist
- Email: manikus681@gmail.com
- Phone: +905368547482
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.