Breath test to measure protein processing during different physical activities
Non-Invasive Modified Breath Test to Determine Anabolic Sensitivity Across Physical Activity States in Healthy Young Adults
This study is testing a breath test to see how different levels of physical activity affect how young adults process protein in their bodies.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 35 Years |
| Sex | All |
| Sponsor | University of Toronto Academic / other |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT06209424 on ClinicalTrials.gov |
What this trial studies
This study aims to refine a breath test method to assess how the body processes protein under various physical activity states, including rest, reduced activity, and resistance exercise. By using a lower amount of dietary amino acids in the breath test, researchers hope to effectively measure the body's anabolic sensitivity and protein synthesis rates. The study focuses on understanding the impact of habitual activity levels on muscle protein synthesis, particularly in healthy young adults. The findings could lead to better strategies for maintaining lean body mass and preventing muscle loss in various populations.
Who should consider this trial
Good fit: Ideal candidates for this study are healthy young adults aged 18-35 with a normal to overweight BMI.
Not a fit: Patients with chronic diseases, recent cancer remission, or those on medications affecting muscle protein synthesis may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could provide insights into optimizing dietary protein intake and exercise regimens to preserve muscle mass, especially in aging populations or those with certain health conditions.
How similar studies have performed: While the approach of using breath tests for protein metabolism is innovative, similar studies have shown the importance of physical activity on protein synthesis, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy young (age: 18-35 years) * BMI between normal to overweight (18.5-29.9 kg/m2) * if oral contraceptive (OC) user, must be on monophasic OCs for at least 3 months prior to study * if non-OC user, then must have regular menstrual cycles (length: 25-35 days) for at least 3 months prior to study and at least 6 months off of OCs Exclusion Criteria: * Chronic disease diagnosis (cardiovascular, thyroid, diabetes) * Current or recent remission of cancer * Regular use of NSAID (except low-dose aspirin), anticoagulants * Use of prescription drugs that would impact muscle protein synthesis (e.g., Statins, Lithium, ADHD medication, etc..) * Insertion of intrauterine device (IUD) - exception: copper * Smoking * Use of illicit drugs (growth hormones, testosterone)
Where this trial is running
Toronto, Ontario
- Goldring Centre for High Performance Sport at the University of Toronto — Toronto, Ontario, Canada (Recruiting)
Study contacts
- Principal investigator: Daniel R Moore, PhD — University of Toronto
- Study coordinator: Daniel R Moore, PhD
- Email: dr.moore@utoronto.ca
- Phone: 4169464088
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.