Brain resilience after a minor ischemic stroke (BREMISS)
Initial Predictors of Long-term Brain Resilience After Minor Ischemic Stroke: a Study Nested in the Brest Stroke Population-based Registry
This project will try to build a model that predicts quality of life more than four years after a minor ischemic stroke using patients' initial clinical data, optional MRI and saliva samples, and questionnaires.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Brest Academic / other |
| Locations | 1 site (Brest) |
| Trial ID | NCT06995040 on ClinicalTrials.gov |
What this trial studies
BREMISS combines retrospective and prospective data from patients with minor ischemic stroke (NIHSS ≤ 5) to create long-term quality-of-life prediction models. Participants complete questionnaires and may provide an optional saliva sample and undergo an optional brain MRI; all available early clinical and imaging data will be used. The study applies conventional statistical methods and AI algorithms to identify which initial characteristics best predict outcomes more than four years after the event. Results aim to clarify long-term trajectories after minor stroke and support individualized follow-up and care planning.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18–74 with a first minor ischemic stroke (NIHSS ≤ 5), recorded in the Brest Stroke Registry, able to give consent and available for more than four years of follow-up with the ability to undergo MRI and provide saliva if willing.
Not a fit: Patients with transient symptoms resolving within one hour with normal imaging, those unable to consent or without the ability to complete long-term follow-up, and people outside the age or registry criteria are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the predictive model could help clinicians identify patients at higher risk of poor long-term quality of life so they can offer targeted follow-up and rehabilitation earlier.
How similar studies have performed: Related predictive models for short- and mid-term stroke outcomes exist and have shown promise, but long-term (>4 years) quality-of-life prediction specifically for minor ischemic stroke using combined statistical and AI approaches remains limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cases of stroke in the Brest Stroke Registry (BSR) * Ability to sign informed consent * Patients followed-up \> 4 years during the study period * NIHSS score ≤ 5 on admission * First stroke above 18 and before 75-year old * Rankin before stroke \< 1 * Possibility to draw saliva samples for genomic study * Possibility to perform Cerebral MRI Exclusion Criteria: * Patients with transient neurological deficits resolving within one hour and normal brain imaging will be excluded. * Not affiliated to social security * Patient under legal protection or deprived of liberty by a judicial or administrative decision * Patient unable to sign informed consent * Patient whose follow-up will be impossible
Where this trial is running
Brest
- CHU de Brest — Brest, France (Recruiting)
Study contacts
- Principal investigator: Serge TIMSIT, Pr — CHU de Brest
- Study coordinator: Serge TIMSIT, Pr
- Email: serge.timsit@chu-brest.fr
- Phone: 298147349
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.