Brain resilience after a minor ischemic stroke (BREMISS)
Official title: Initial Predictors of Long-term Brain Resilience After Minor Ischemic Stroke: a Study Nested in the Brest Stroke Population-based Registry
Run by University Hospital, Brest · NCT06995040 · Data updated 2026-11-12
This project will try to build a model that predicts quality of life more than four years after a minor ischemic stroke using patients' initial clinical data, optional MRI and saliva samples, and questionnaires.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | University Hospital, Brest Academic / other |
| Locations | 1 site (Brest) |
| Status | Recruiting |
| Started | June 18, 2025 |
| Main results expected | December 18, 2027 |
| Study ends | December 18, 2028 |
| Registry record updated | February 23, 2026 |
| Trial ID | NCT06995040 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18–74 with a first minor ischemic stroke (NIHSS ≤ 5), recorded in the Brest Stroke Registry, able to give consent and available for more than four years of follow-up with the ability to undergo MRI and provide saliva if willing.
✕Probably not a fit
Patients with transient symptoms resolving within one hour with normal imaging, those unable to consent or without the ability to complete long-term follow-up, and people outside the age or registry criteria are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
BREMISS combines retrospective and prospective data from patients with minor ischemic stroke (NIHSS ≤ 5) to create long-term quality-of-life prediction models. Participants complete questionnaires and may provide an optional saliva sample and undergo an optional brain MRI; all available early clinical and imaging data will be used. The study applies conventional statistical methods and AI algorithms to identify which initial characteristics best predict outcomes more than four years after the event. Results aim to clarify long-term trajectories after minor stroke and support individualized follow-up and care planning.
Why it matters
Potential benefit: If successful, the predictive model could help clinicians identify patients at higher risk of poor long-term quality of life so they can offer targeted follow-up and rehabilitation earlier.
How similar studies have gone: Related predictive models for short- and mid-term stroke outcomes exist and have shown promise, but long-term (>4 years) quality-of-life prediction specifically for minor ischemic stroke using combined statistical and AI approaches remains limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cases of stroke in the Brest Stroke Registry (BSR) * Ability to sign informed consent * Patients followed-up \> 4 years during the study period * NIHSS score ≤ 5 on admission * First stroke above 18 and before 75-year old * Rankin before stroke \< 1 * Possibility to draw saliva samples for genomic study * Possibility to perform Cerebral MRI Exclusion Criteria: * Patients with transient neurological deficits resolving within one hour and normal brain imaging will be excluded. * Not affiliated to social security * Patient under legal protection or deprived of liberty by a judicial or administrative decision * Patient unable to sign informed consent * Patient whose follow-up will be impossible
Where it's running
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CHU de Brest
Brest, France Recruiting
Study contacts
- Principal investigator: Serge TIMSIT, Pr — CHU de Brest
- Study coordinator: Serge TIMSIT, Pr
- Email: serge.timsit@chu-brest.fr
- Phone: 298147349
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.