Brain connectivity and corticospinal excitability in response to moderate hypoxia
Run by Universite du Littoral Cote d'Opale · NCT07516028 · Data updated 2026-11-12
Researchers will test how resting brain activity and motor responsiveness change when healthy adults experience moderate hypoxia, either intermittent or continuous.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 36 (estimated) |
| Sponsor | Universite du Littoral Cote d'Opale Academic / other |
| Locations | 1 site (Loos, Hauts-de-France) |
| Status | Recruiting |
| Started | March 15, 2026 |
| Main results expected | December 20, 2026 |
| Study ends | December 20, 2026 |
| Registry record updated | September 21, 2026 |
| Trial ID | NCT07516028 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Healthy adults aged 18 to 65 without neurological or significant cardiopulmonary conditions, right- or left-handed, and able to provide informed consent in French.
✕Probably not a fit
Individuals with BMI over 30, sleep apnea, cardiac or respiratory disorders, current smokers, or contraindications to TMS may not benefit and are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of continuous and intermittent moderate hypoxia on resting-state brain dynamics in healthy adults using EEG and fNIRS alongside motor-evoked potential measures. Participants will undergo hypoxic and normoxic conditions while brain activity and haemodynamics are recorded, aiming to identify functional and vascular markers associated with exposure. The approach combines noninvasive brain monitoring with transcranial magnetic stimulation to characterize neurophysiological responses to different hypoxia patterns. The findings could help explain how moderate hypoxia influences brain networks and neuroplasticity in humans. The study is conducted under strict inclusion criteria and safety monitoring at a single site.
Why it matters
Potential benefit: If successful, results could advance understanding of how moderate hypoxia affects brain function and potentially inform non-drug strategies to support brain health.
How similar studies have gone: Prior research suggests intermittent hypoxia can drive cardiometabolic and potentially cognitive adaptations, but detailed human resting-state brain dynamics under hypoxia remain underexplored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female aged 18 to 65 years * Healthy right- or left-handed individuals with no self-reported neurological disorders or history of neurological conditions (e.g., epilepsy, stroke, brain or spinal surgery, or neurological diseases affecting motor or sensory function such as multiple sclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's) * Individuals who have provided informed consent and have sufficient proficiency in French * Participants affiliated with, or beneficiaries of, a social security scheme Exclusion Criteria: * Body mass index (BMI) greater than 30 kg/m² * Diagnosed and untreated obstructive sleep apnoea syndrome * Inability to provide informed consent * History of cardiac (e.g., ischaemic heart disease, heart failure) and/or respiratory disorders (e.g., COPD, chronic respiratory insufficiency, persistent or uncontrolled asthma) * Current smokers * Contraindications to TMS (e.g., uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp lesions, elevated intracranial pressure, cerebrospinal fluid shunt) * Use of psychotropic medication * Individuals under legal guardianship or curatorship * Pregnant or breastfeeding women * Participants who have flown by air or travelled to terrestrial altitudes above 1500 metres within the seven days prior to inclusion
Where it's running
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Eurasport
Loos, Hauts-de-France, France Recruiting
Study contacts
- Study coordinator: Ségolène M. R. Guérin, PhD
- Email: segolene.guerin@univ-littoral.fr
- Phone: +33 3 74 00 82 13
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.