Clinical trial Recruiting at 1 site Interventional Ages 18 to 35

Motor cortex changes when learning a brand-new movement

Official title: Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study

Run by Universite du Littoral Cote d'Opale · NCT07455461 · Data updated 2026-11-12

This trial will test whether practicing a brand-new motor task increases motor system excitability in healthy right-handed adults over three separate sessions.

Quick facts

Study typeInterventional
Ages18 Years to 35 Years
SexAll
Enrollment40 (estimated)
SponsorUniversite du Littoral Cote d'Opale
Academic / other
Locations1 site (Loos)
StatusRecruiting
StartedFebruary 25, 2026
Main results expectedJune 2027
Study endsJune 2027
Registry record updatedMarch 6, 2026
Trial IDNCT07455461 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are healthy, right-handed adults without contraindications to transcranial magnetic stimulation who can attend three in-person sessions.

Probably not a fit

People who are pregnant, have contraindications to TMS, active neurological disorders, or who cannot attend the sessions are unlikely to benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial enrolls healthy, right-handed adults who perform a de novo motor learning task across three practice sessions separated by different time intervals. Corticospinal excitability and intracortical reorganization in primary motor cortex (M1) will be measured with transcranial magnetic stimulation before and after practice to quantify physiological change. Behavioral learning (performance improvements) will also be recorded across sessions to relate skill acquisition to neurophysiological changes. Comparisons will examine whether excitability increases and connectivity reorganizes consistently across sessions and intervals.

Why it matters

Potential benefit: If successful, results could help shape better-timed training or rehabilitation approaches to improve motor recovery after injury.

How similar studies have gone: Previous TMS studies using simple motor tasks have often reported increased corticospinal excitability and cortical reorganization, but results have been variable and not uniformly replicated.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* right-handed
* healthy
* having signed an informed consent form

Exclusion Criteria:

* counter-indication to transcranial magnetic stimulation
* pregnancy

Where it's running

  • Eurasport
    Loos, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.