Motor cortex changes when learning a brand-new movement
Official title: Cortical Excitability During de Novo Motor Learning in Healthy Subjects : an Exploratory Longitudinal Study
Run by Universite du Littoral Cote d'Opale · NCT07455461 · Data updated 2026-11-12
This trial will test whether practicing a brand-new motor task increases motor system excitability in healthy right-handed adults over three separate sessions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 35 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Universite du Littoral Cote d'Opale Academic / other |
| Locations | 1 site (Loos) |
| Status | Recruiting |
| Started | February 25, 2026 |
| Main results expected | June 2027 |
| Study ends | June 2027 |
| Registry record updated | March 6, 2026 |
| Trial ID | NCT07455461 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal participants are healthy, right-handed adults without contraindications to transcranial magnetic stimulation who can attend three in-person sessions.
✕Probably not a fit
People who are pregnant, have contraindications to TMS, active neurological disorders, or who cannot attend the sessions are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial enrolls healthy, right-handed adults who perform a de novo motor learning task across three practice sessions separated by different time intervals. Corticospinal excitability and intracortical reorganization in primary motor cortex (M1) will be measured with transcranial magnetic stimulation before and after practice to quantify physiological change. Behavioral learning (performance improvements) will also be recorded across sessions to relate skill acquisition to neurophysiological changes. Comparisons will examine whether excitability increases and connectivity reorganizes consistently across sessions and intervals.
Why it matters
Potential benefit: If successful, results could help shape better-timed training or rehabilitation approaches to improve motor recovery after injury.
How similar studies have gone: Previous TMS studies using simple motor tasks have often reported increased corticospinal excitability and cortical reorganization, but results have been variable and not uniformly replicated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * right-handed * healthy * having signed an informed consent form Exclusion Criteria: * counter-indication to transcranial magnetic stimulation * pregnancy
Where it's running
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Eurasport
Loos, France Recruiting
Study contacts
- Study coordinator: Pierre D Morel, Dr
- Email: pierre.morel@univ-littoral.fr
- Phone: 0033781692692
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.