Brain-computer interface neurofeedback to improve thinking skills after brain injury
Official title: Cognitive Rehabilitation Using Neurofeedback With Brain-computer Interface - CONNECT: A Prospective Randomised Controlled Trial
Run by KK Women's and Children's Hospital · NCT07828496 · Data updated 2026-11-12
Researchers are testing a brain-computer interface neurofeedback program to see if it can improve attention, memory, and executive function in kids and teens who have had a brain injury or epilepsy, compared with standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 7 Years to 21 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | KK Women's and Children's Hospital Government |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | February 1, 2028 |
| Study ends | June 30, 2028 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT07828496 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children and adolescents aged 7 to 21 with acquired brain injury (e.g., TBI, stroke, encephalitis, brain tumor) or epilepsy who can participate in neuropsychological assessments and tolerate the neurofeedback sessions.
✕Probably not a fit
Participants who have contraindications to neurofeedback, cannot cooperate with cognitive assessments, or whose condition is unlikely to respond to the intervention may see no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study tests a brain-computer interface (BCI) with neurofeedback delivered through 3D game sessions to children and adolescents aged 7 to 21 years who have acquired brain injuries or epilepsy. The study will also enroll a normative group without brain injury to establish baseline EEG measures of attention and relaxation. Key questions are whether EEG markers of sustained, selective, and relaxed attention reflect cognitive impairment after ABI, and whether the BCI-NFT program can improve cognitive and behavioral outcomes compared with standard care. The study uses EEG-derived measures and behavioral assessments to track changes in attention, memory, and executive function. Lead involvement is KK Women’s and Children’s Hospital in Singapore, with no listed collaborators.
Why it matters
Potential benefit: If successful, participants may experience improvements in attention, memory, and executive function, potentially translating to better daily functioning.
How similar studies have gone: Neurofeedback and EEG-based markers have shown promise in related cognitive rehabilitation approaches, but this exact BCI-NFT program in ABI/epilepsy youth is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Normaitve cohort: \- Patients with no history of epilepsy Inclusion Criteria: * Post acquired brain injury (stroke, encephalitis, brain tumour, traumatic brain injury) * Epilepsy Exclusion Criteria: * History of photosensitive seizures * Diagnosis of intellectual disability * Presence of psychotic symptoms * Diagnosis of attention deficit and hyperactivity disorder * Diagnosis of autism spectrum disorder * Children on methylphenidate * Children who are unable to cooperate with neuropsychological assessment of cognitive function
Where it's running
-
KK Women's and Children's Hospital
Singapore, Singapore Recruiting
Study contacts
- Study coordinator: Jia Hui Teo
- Email: teo.jia.hui@singhealth.com.sg
- Phone: +6563926042
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.