Boosting physical reserve to help frail older adults stay resilient.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial will assign 224 community-dwelling older adults with physical frailty to either a 3-month progressive, moderate-intensity combined aerobic and resistance training program (ATRT) or to usual care. Participants will complete physical performance testing (including the SPPB), cognitive screening (MoCA), and brain MRI to measure white matter hyperintensities and neural network connectivity before and after the intervention. The study will compare changes in physical reserve, neural network organization—particularly Dorsal Attention Network connectivity—and the relationships among exercise, neural networks, and functional outcomes. Investigators aim to see whether exercise-induced increases in physical reserve can moderate the impact of WMH on cognitive and physical function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. are community-dwelling (i.e., not residing in a nursing home or extended care unit) ;
2. scored \< 9/12 on the SPPB;
3. scored \>18/30 on the MoCA;
4. are able to walk independently; use of walking aid is acceptable;
5. are able to safely engage in exercise as indicated by the Physical Activity Readiness Questionnaire Plus33 and confirmed by their physician;
6. have internet at home; and
7. are able to provide written informed consent.

Exclusion Criteria:

1. diagnosed with dementia or stroke;
2. self-report engaging in strength and balance training exercises \> two-times-per-week in the 3 months prior to screening;
3. unable to understand, speak, and read Cantonese/Chinese/English proficiently; and
4. contraindications for MRI such as MRI-incompatible implants.

Where it's running

• The Hong Kong Polytechnic University, Department of Rehabilitation Sciences
  Hong Kong, Hong Kong, Hong Kong Recruiting

Study contacts

• Study coordinator: Chun Liang HSU, PhD
• Email: chun-liang.hsu@polyu.edu.hk
• Phone: 852-27666755

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.