Blocking the airway to improve heart surgery outcomes
Effect of Topical Airway Block on Hemodynamic Stability Post Induction of Anaesthesia in Cardiac Surgeries
This study is testing if using a lidocaine spray to block the airway can help heart surgery patients have a smoother anesthesia experience and recover better by reducing the need for strong painkillers.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 106 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ain Shams University Academic / other |
| Locations | 2 sites (Cairo and 1 other locations) |
| Trial ID | NCT06395727 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of a topical airway block using lidocaine spray on hemodynamic stability during the induction of anesthesia in patients undergoing elective cardiac surgery. The study aims to reduce the reliance on high doses of opioids, which can lead to hemodynamic instability, by targeting the sensory pathways involved in the stress response to intubation. By minimizing opioid use, the trial seeks to enhance patient safety and improve recovery times post-surgery. The approach is based on the understanding that managing hemodynamic changes is critical during the induction phase of anesthesia.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who are scheduled for elective cardiac surgery.
Not a fit: Patients who may not benefit include those with severe cardiac conditions, such as aortic dissection or severe valve stenosis, and those undergoing emergency surgeries.
Why it matters
Potential benefit: If successful, this approach could lead to safer cardiac surgeries with fewer complications related to hemodynamic instability.
How similar studies have performed: While the use of airway blocks in anesthesia is established, this specific approach targeting hemodynamic stability in cardiac surgery is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Undergoing elective cardiac surgery. * Age: above 18 Exclusion Criteria: * • Pregnant or breast-feeding women * Emergency surgery * Anticipated difficult airway * Allergy to any of the drugs used in the study * Cannot cooperate to complete topical anaesthesia (with mental disorders or unable to communicate) * Use of a left ventricular assist device, IAB or ECMO prior to surgery * Presence of aortic dissection * EF\<40 % * Severe mitral valve stenosis or severe aortic valve stenosis
Where this trial is running
Cairo and 1 other locations
- Abdallah — Cairo, Egypt (Recruiting)
- Abdallah Mahmoud Zaki Soudi — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.