Biomarker-guided decisions about preventive TB treatment
PRecision biomArker-Guided MAnagement of TuberculosIs Contacts: a Discrete Choice Experiment
This project tests what influences adults tested for latent TB when deciding whether to start preventive treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 430 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University College, London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT07024836 on ClinicalTrials.gov |
What this trial studies
The study uses two stages: first, up to 30 semi-structured interviews with adults who have been or are being tested for latent TB infection as part of routine clinical screening. Findings from the qualitative interviews will be used to design a discrete choice experiment (DCE). The DCE will quantify how patients and healthcare providers trade off future TB risk against attributes of preventive treatment when making decisions. Participants will be purposively sampled to include migrants from high-incidence countries, recent TB contacts, and people screened before immunosuppression or via occupational health.
Who should consider this trial
Good fit: Adults (age 18+) who have been tested for latent TB infection or are eligible for LTBI testing, including recent migrants from high-incidence countries, recent TB contacts, and people screened before immunosuppression or through occupational health.
Not a fit: People who cannot provide informed consent, children, those not undergoing LTBI testing, or people with active TB disease are not expected to benefit from participation.
Why it matters
Potential benefit: If successful, this work could help target preventive TB treatment to people most likely to accept and benefit, increasing uptake and avoiding unnecessary treatment.
How similar studies have performed: Qualitative interviews and discrete choice experiments have been used previously to study treatment preferences in TB and other diseases, though combining these methods to inform biomarker-guided preventive TB treatment is relatively new.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (aged ≥18 years) who have been tested for latent TB infection in routine clinical services, or are eligible for testing. Eligible people for testing include migrants from countries with high TB incidence (entered UK within 5 years), people with recent contact with a person with TB disease, and people eligible for LTBI screening prior to starting immunosuppression or through occupational health testing. Exclusion Criteria: * Unable to provide informed consent.
Where this trial is running
London
- Whittington Hospital — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Rishi K Gupta, PhD
- Email: r.gupta@ucl.ac.uk
- Phone: 020 3549 5979
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.