Biomarker-based Alzheimer's disease cohort (BASIC)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center cohort will recruit patients meeting NIA-AA criteria for AD-related mild cognitive impairment or probable AD who are amyloid-positive by PET or cerebrospinal fluid testing. Participants will be followed and characterized with clinical assessments and biomarker data to explore links between biomarkers, clinical features, and progression. Investigators will analyze potential risk factors for faster decline and use those findings to build a biomarker-based early warning model of progression rate. The cohort is intended to create a resource for future AD research and to enable earlier, more precise prevention strategies for patients in China.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* (1) Patients aged 40 years or older;
* (2) Visiting Xuanwu Hospital, Capital Medical University;
* (3) Meeting the core clinical diagnostic criteria for Alzheimer's disease (AD) - related mild cognitive impairment or probable AD according to the NIA-AA (2011);
* (4) Amyloid positivity confirmed by amyloid PET or cerebrospinal fluid biomarker tests;
* (5) Providing informed consent.

Exclusion Criteria:

* (1) Individuals who are unable to complete the assessment due to severe psychological or physiological disorders.

Where it's running

• Xuanwu Hospital of Capital Medical University
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Liyang Liu
• Email: liuliyang@xwhosp.org
• Phone: 17888828131

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.