Best time to eat mangoes to help control blood sugar in prediabetes

Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Relation to Meal in Prediabetic Individuals

This project will test whether eating mangoes before, during, or after a meal changes blood sugar and inflammation in people with prediabetes.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 30 (estimated)
• Ages: 20 Years to 60 Years
• Sex: All
• Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology (Industry-sponsored)
• Locations: 1 site (Chicago, Illinois)
• Trial ID: NCT06986161 on ClinicalTrials.gov

What this trial studies

The study enrolls adults with prediabetes to compare metabolic and inflammatory responses after consuming mango versus a control beverage at different times relative to a meal. Participation lasts about five weeks and includes one screening visit and four full-day test visits during which blood and urine samples are collected over roughly eight hours. Researchers will measure blood glucose, HbA1c, inflammatory markers, and levels of mango-derived bioactive compounds to track absorption and bodily processing. The crossover design isolates the timing of mango intake to determine when mango consumption produces the most favorable metabolic response.

Who should consider this trial

Good fit: Adults aged 20–60 with prediabetes (fasting glucose 100–125 mg/dL or HbA1c 5.7–6.4%), BMI 25–35 kg/m2, who are non-smokers and can attend multiple in-person visits are ideal candidates.

Not a fit: People with diabetes outside the eligibility ranges, pregnant or breastfeeding individuals, those with mango allergies or on medications that interfere with metabolism, and those unable to make the required clinic visits are unlikely to receive benefit from participating.

Why it matters

Potential benefit: If successful, the results could provide simple, food-based timing advice to help people with prediabetes reduce blood sugar spikes and inflammation.

How similar studies have performed: Prior small human and animal studies suggest mango or its bioactives can blunt post-meal glucose rises and reduce inflammation, but the specific effects of timing mango consumption in prediabetes remain under-studied.

Eligibility criteria

Inclusion Criteria:

* Be between 20-60 years old.
* Have a BMI of 25-35 kilograms per square meter.
* Have fasting blood glucose between 100-125 milligrams per deciliter or Glycated hemoglobin (HbA1c) between 5.7-6.4%.
* Be non-smokers for at least 12 months.
* Be generally healthy, with no major organ-related diseases.
* Not take medications or supplements that could interfere with the study.
* Be able to follow study procedures, including dietary restrictions and scheduled visits.

Exclusion Criteria:

* Smoke, vape, or use marijuana.
* Have allergies or intolerance to mangoes or study foods.
* Have blood pressure above 160/100 millimeters of Mercury.
* Have fasting blood glucose above 125 milligrams per deciliter.
* Have a history of major heart disease, stroke, or cancer in the past five years.
* Be pregnant, planning to become pregnant, or breastfeeding.
* Take anti-inflammatory drugs or certain dietary supplements.
* Have had major surgery or trauma in the past two months.
* Follow extreme diets (e.g., vegan, Atkins).
* Have used antibiotics in the last six weeks.
* Have a history of eating disorders or substance abuse in the past two years.
* Drink more than three cups of coffee or tea per day.
* Have donated blood in the last three months.
* Be professional athletes or do excessive exercise.
* Have had weight changes of more than 11 pounds in the past two months.
* Work overnight shifts.

Where this trial is running

Chicago, Illinois

• Clinical Nutrition Research Center — Chicago, Illinois, United States (Recruiting)

Study contacts

• Principal investigator: Indika Edirisinghe, PhD. — Illinois Institute of Technology
• Study coordinator: Amandeep K. Sandhu, PhD.

Conditions Pre Diabetes