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Best breathing strategy during pediatric cardiac arrest

OPTImal Ventilation to Improve Pediatric Cardiac Arrest Outcomes (OPTI-VENT)

Not applicable Interventional Children's Hospital of Philadelphia · NCT07114510

This study will test whether the OPTI-VENT bundle of breathing adjustments during CPR helps children who have a cardiac arrest in the hospital survive to discharge with good brain function.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1530 (estimated)
Ages37 Weeks to 18 Years
SexAll
SponsorChildren's Hospital of Philadelphia Academic / other
Locations20 sites (Orange, California and 19 other locations)
Trial IDNCT07114510 on ClinicalTrials.gov

What this trial studies

The trial enrolls children who receive at least one minute of in-hospital CPR and who have an invasive airway in place at the start of CPR or have an airway placed within the first five minutes. Enrolled patients are allocated to receive the OPTI-VENT bundle, a transition strategy, or standard care, and clinical teams follow the assigned ventilation approach during resuscitation. The primary outcome is survival to hospital discharge with a favorable neurological outcome (Pediatric Cerebral Performance Category Score 1–2 or no change from baseline). The study is conducted across several large U.S. pediatric centers to capture real-world resuscitation events.

Who should consider this trial

Good fit: Children in the hospital who have a cardiac arrest, receive at least one minute of CPR, and have an invasive airway in place at the start of CPR or placed within the first five minutes are eligible.

Not a fit: Children who receive CPR as part of end-of-life care, who were already declared brain dead before the event, who were admitted because of an out-of-hospital arrest, or who were on veno-arterial ECMO at the start of CPR are excluded and unlikely to benefit from this protocol.

Why it matters

Potential benefit: If successful, the OPTI-VENT bundle could increase the number of children who leave the hospital after cardiac arrest with good neurological function.

How similar studies have performed: Ventilation-focused resuscitation strategies have physiologic rationale and mixed findings in adults, but randomized pediatric evidence is limited, so the OPTI-VENT bundle is a relatively novel pediatric approach.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
* Received at least 1 minute of CPR.

Exclusion Criteria:

* Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
* Brain death determination prior to the CPR event.
* Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
* Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Where this trial is running

Orange, California and 19 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Cardiac ArrestPediatric
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.