Best breathing strategy during pediatric cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial enrolls children who receive at least one minute of in-hospital CPR and who have an invasive airway in place at the start of CPR or have an airway placed within the first five minutes. Enrolled patients are allocated to receive the OPTI-VENT bundle, a transition strategy, or standard care, and clinical teams follow the assigned ventilation approach during resuscitation. The primary outcome is survival to hospital discharge with a favorable neurological outcome (Pediatric Cerebral Performance Category Score 1–2 or no change from baseline). The study is conducted across several large U.S. pediatric centers to capture real-world resuscitation events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Invasive airway in place at the start of CPR or airway placed within the first 5 minutes
* Received at least 1 minute of CPR.

Exclusion Criteria:

* Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care.
* Brain death determination prior to the CPR event.
* Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes).
* Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Where it's running

• Choc
  Orange, California, United States Recruiting
• Lucile Packard Children's Hospital Stanford
  Palo Alto, California, United States Recruiting
• Children's Hospital Colorado
  Denver, Colorado, United States Recruiting
• Nemours Children's Health
  Wilmington, Delaware, United States Recruiting
• Children's Healthcare of Atlanta
  Atlanta, Georgia, United States Recruiting
• Riley Children's Health
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: Robert Sutton, MD, MSCE — Children's Hospital of Philadelphia
• Study coordinator: CHOP RSC Clinical Research Program Manager
• Email: grahamk1@chop.edu
• Phone: 215-590-1859

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.