Basivertebral Nerve Ablation for Axial Low Back Pain
Official title: Monopolar Basivertebral Nerve Ablation for Axial Low Back Pain - Single-Arm Proof-of-Concept Study
Run by EPC Education s.r.o. · NCT07559890 · Data updated 2026-11-12
This trial tests whether monopolar basivertebral nerve ablation can reduce pain for adults with chronic axial low back pain who have certain MRI changes and have not benefited enough from other treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | EPC Education s.r.o. Academic / other |
| Locations | 3 sites (Prague and 2 other locations) |
| Status | Recruiting |
| Started | May 4, 2026 |
| Main results expected | May 2027 |
| Study ends | May 2029 |
| Registry record updated | July 31, 2026 |
| Trial ID | NCT07559890 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with chronic axial low back pain (≥6 months) and Modic type I/II changes at ≥1 level, who have not benefited sufficiently from prior conservative care and diagnostic blocks with negative or limited response.
✕Probably not a fit
Patients whose pain is driven by non-axial sources, those with previous spinal surgery at the target level, or with contraindications to the procedure may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study evaluates the safety and effectiveness of monopolar basivertebral nerve ablation (BVNA) for axial low back pain. The procedure uses fluoroscopic guidance to apply controlled radiofrequency energy to interrupt basivertebral nerve fibers within the vertebral body. Eligible participants have chronic axial low back pain with Modic changes and have not responded adequately to conservative care or prior diagnostic blocks. Post-procedure follow-up focuses on pain, function, and any procedure-related adverse events. The trial emphasizes method optimization to refine energy delivery and ensure patient safety.
Why it matters
Potential benefit: If successful, patients may experience meaningful pain relief and improved function due to targeted nerve interruption.
How similar studies have gone: Prior basivertebral nerve interventions have shown promise in select patients, but results can vary and this approach remains an area of active investigation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Axial low back pain (with or without lateral component). * Presence of Modic type I or II changes at ≥ 1 level. * Age over 18 years. * Duration of pain ≥ 6 months. * Completion of full conservative management for ≥ 3 months. * Medial Branch Block (MBB) test performed with negative results/ or Facet Denervation done with unsatisfactory outcome (less than 50% improvement) after positive MBB test. Exclusion Criteria: * Coagulation disorders. * Platelet abnormalities. * Lack of informed consent. * Generalized solid tumor. * Hematopoietic malignancy. * Radicular pain. * Alternative primary pain generators other than axial low back pain. * Previous spinal surgery. * Targeted level located above L3/L4 * Osteoporosis
Where it's running
-
EuroPainClinics Praha a.s
Prague, Czechia Recruiting -
Poliklinika Terasa
Košice, Slovakia Not yet recruiting -
Europainclinics Sweden
Umeå, Sweden Not yet recruiting
Study contacts
- Study coordinator: Michal Matias, MD, FIPP
- Email: matias@europainclinics.com
- Phone: +420602246127
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.