Basal LH threshold for diagnosing central precocious puberty
Official title: Can LHRH Stimulation Testing Be Avoided? Evaluation of a Basal LH Threshold in Central Precocious Puberty
Run by University Hospital, Strasbourg, France · NCT07864116 · Data updated 2026-11-12
This study tests whether a single, baseline LH measurement can correctly diagnose central precocious puberty in kids and reduce the need for the LHRH stimulation test.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 4 Years to 11 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | March 2, 2026 |
| Main results expected | November 2, 2026 |
| Study ends | January 2, 2027 |
| Registry record updated | October 7, 2026 |
| Trial ID | NCT07864116 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 4 to 11 years who underwent LHRH stimulation testing for suspected central precocious puberty between 2019 and 2024 and provided data reuse consent.
✕Probably not a fit
Patients whose puberty onset is due to non-central causes or who do not meet the basal LH threshold may not benefit from a reduced reliance on LHRH testing.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This retrospective, single-center observational study will review pediatric cases evaluated for suspected central precocious puberty from 2019 to 2024. It aims to identify a basal LH threshold that achieves high specificity for diagnosis, potentially reducing the number of LHRH stimulation tests performed. Secondary analyses will evaluate overall diagnostic performance and explore clinical and biological factors that may influence LH levels. Findings could streamline diagnostic pathways and minimize unnecessary testing in children presenting with early puberty signs.
Why it matters
Potential benefit: If successful, clinicians could reliably diagnose central precocious puberty with fewer LHRH stimulation tests, saving time and reducing patient burden.
How similar studies have gone: Past research in pediatric endocrinology has explored diagnostic thresholds for LH, with variable results; this study builds on prior work by focusing on a specific basal LH cutoff with high specificity.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children aged 4 to 11 years * Underwent LHRH stimulation testing for suspected precocious puberty between 01/01/2019 and 01/01/2024 * No written opposition to reuse of medical data Exclusion Criteria: * Written opposition to data reuse * Age \<4 years or \>11 years 11 months * LHRH test performed for indications other than suspected precocious puberty
Where it's running
-
Service de Pédiatrie 1 - CHU de Strasbourg - France
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Sylvie Rossignol, MD, PhD
- Email: sylvie.rossignol@chru-strasbourg.fr
- Phone: 33 3 88 12 77 34
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.