Bariatric surgery and biological aging in Nantes patients
Nantes Bariatric Surgery Cohort
This project will see if bariatric surgery changes biological age and related factors like fat‑cell function, gut bacteria, and daily biological rhythms in adults undergoing surgery at Nantes University Hospital.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Nantes University Hospital Academic / other |
| Locations | 1 site (Nantes, Loire-Atlantique) |
| Trial ID | NCT06625762 on ClinicalTrials.gov |
What this trial studies
The Nantes Bariatric Surgery Cohort is an observational study enrolling 300 adults scheduled for bariatric surgery and following them over approximately 3.5 years. Participants have pre‑operative, peri‑operative, and post‑operative visits during which clinical measurements, questionnaires, blood tests, anthropometrics, and biocollections (including samples for microbiota and cellular analyses) are collected. The study will compare markers of biological age, adipocyte dysfunction, microbiota composition, and circadian/biological rhythms before and after surgery. Analyses will look for links between changes in those biological measures and changes in biological age.
Who should consider this trial
Good fit: Adults (≥18 years) who are enrolled in the Nantes University Hospital bariatric surgery pathway with BMI ≥35 kg/m2 with complications or ≥40 kg/m2, who can consent and have social security coverage, are ideal candidates.
Not a fit: People who are pregnant or breastfeeding, under legal protection, deprived of liberty, or not undergoing bariatric surgery at the Nantes center are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the results could help personalize prevention and follow‑up after bariatric surgery by identifying biological changes tied to aging and metabolic recovery.
How similar studies have performed: Preclinical and observational studies have linked adipose inflammation to accelerated aging, but a comprehensive perioperative human cohort linking bariatric surgery, adipocyte function, microbiota, rhythms, and biological age is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria : Individuals selected for bariatric surgery (starting the BC pathway within the Nantes University Hospital bariatric unit). Inclusion criteria are those of the Bariatric Surgery program. * male or female, adult over 18 years of age * BMI ≥ 35 kg/m2 with complication(s) or ≥ 40 kg/m2 with or without complication (the list of eligible complications is referenced in HAS 2024 recommendations). In the event of a change in access to bariatric surgery, this threshold could be revised without any substantial change to the protocol. * having consented to their participation in the cohort * participant affiliated to or benefiting from a social security scheme Exclusion Criteria : * Persons protected by law (guardianship or trusteeship) or deprived of their freedom, * Pregnant women (contraindication to CB) or nursing mothers.
Where this trial is running
Nantes, Loire-Atlantique
- Nantes University Hospital — Nantes, Loire-Atlantique, France (Recruiting)
Study contacts
- Principal investigator: David JACOBI, PU-PH — Nantes University Hospital
- Study coordinator: David JACOBI, PU-PH
- Email: david.jacobi@chu-nantes.fr
- Phone: 33 2 53 48 27 09
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.